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《Lishizhen Medicine and Materia Medica Research》 2011-04
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Screening of Anti-Viral Active Sites from Artemisia scoparia Waldst.et Kit

WANG Yu-mei1,WANG Lin-lin2,YAO Hua2,LIU Yan2,WANG Xue2,HUANG Hua2(1.Pharmacological College of Shihezi University,Shihezi,Xinjiang,832000 China;2.Pharmacological Institute of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830004,China)  
Objective To screen the anti-viral active site from Artemisia scoparia Waldst.et Kit.Methods The cell culture technique in vitro was used in MDCK cells to get TC50 of different active sites from Artemisia scoparia Waldst.et Kit.50% in hibitor concentration(IC50) and the select index(SI) were mesasured by cytopathic effect(CPE).The mice were infected with influenza virus PR8-M5 from nose.The death rate and the mean survival days of infected mice were observed to evaluate the therapeutic efficacy of different active sites from Artemisia scoparia Waldst.et kit.Results The cytopathic effect of the active H4 included by influenza virus was inhibited remarkably,with IC50 of 35.3,84.0 μg/ml and the SI of 9.9,4.1.At the dose of 0.4 g/kg body weight the survival rate was increased remarkably.Conclusion The active H4 of Artemisia scoparia Waldst.et Kit exhibits both anti-influenza activity in vitro and in vivo.
【Fund】: 国家自然科学基金(No.30760307)
【CateGory Index】: R285.5
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