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《Lishizhen Medicine and Materia Medica Research》 2011-04
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Absorption Characteristics of the Molecule-Imprinted Polymer of Pleuromutilin

WANG Xin-yang,REN Ping-ping,ZHANG Li-ying,QIU Wen-qian,CHEN Guang-tong(Medical School of Nantong University,Nantong,Jiangsu 226000,China)  
Objective To explore the synthetic method of artificial simulating receptor of pleuromutilin.Methods The molecule-imprinted polymer of pleuromutilin was primarily prepared with acrylatamide as monomer and N,N'-MethylenebisAcrylamide as crossing-linker through molecularly imprinting technology on the gelatin method,and the absorbance value of its absorption solution was measured by UV spectrometerscopy,and the absorption characteristics of the molecule-imprinted polymer of pleuromutilin was also identified and the absorption effect of different quantities of monomers on the polymer was also observed.Results The absorption of the prepared molecularly imprinted polymer on the template molecule pleuromutilin was at up 26%～38% that of the non-imprinted polymer on the compound.Conclusion The molecule-imprinted polymer of pleuromutilin has certain selective absorption capacity for the template molecule and some characteristics of receptor of pleuromutilin.
【Key Words】： Molecular receptor Molecule-imprinted polymer Pleuromutilin Absorption
【Fund】： 江苏省高校自然科学基金(No.08KJD350003);; 江苏省大学生2008年创新项目;; 南通大学自然科学研究资金资助项目(No.07Z086)
【CateGory Index】： R284.2
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