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《Lishizhen Medicine and Materia Medica Research》 2012-01
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Effects of Preventive Intra-Articular Injection of Radix Salvias Miltionrrfh1zae and Sodium Hyaluronate on Cartilage Degeneration of Osteoarthritis in Rabbit Knee Jionts

DUAN Kan, YUAN Chang-shen, LIU Yu-xiang, YAO Hong-yi, MEI Qi-jie, PAN Ben-zhou(The First Affiliated Hospital of Guangxi TCM University,Nanning 530023,China)  
Objective To observe the preventive effects of intra-articular injection of Radix Salviae Miltiorrhizae and Sodium Hyaluronate against cartilage degeneration of osteoarthtitis rabbit knee joint and the mechanism of knee osteoarthritis. Methods Knee osteoarthritis models were created by cuting off the anterior cruciate ligament and medial collateral ligament in the knee joint,80 adult Japanese white rabbits were divided randomly into 4 groups: Group A,Group B,Group C,Group D.After taking drug for 4 and 8 weeks,the rabbits were killed and the joints gross observing,histological analysis and examination of cell apoptosis were done. Results After 4 and 8weeks,the rabbits were killed,and the inferior articular cartilage of the femoral condoyle was got for histological analysis and examination of cell apoptosis.The score of articular cartilage degeneration and the number of apoptosis cells of cartilage in group B,C or D were smaller than that in group A,and the mean score in group D was smaller than that in group B or C(P0.05).With the same B,C or D group was compared,the score of articular cartilage degeneration and the number of apoptosis cells of cartilage after 4 and 8 weeks had no significant difference(P0.05),and with the same A group was compared the score of articular cartilage degeneration and the number of apoptosis cells of cartilage after 4 and 8 weeks had significant difference(P0.05). Conclusion In early OA,preventive intra-articular injection of Radix Salviae Miltiorrhizae and Sodium Hyaluronate can significantly delay cartilage degeneration,and provide an experimental basis for early prevention and treatment of OA.
【Fund】: 广西壮族自治区自然科学基金(No.0542104)
【CateGory Index】: R684.3
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