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《Lishizhen Medicine and Materia Medica Research》 2012-03
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Research Progress and Strategy in Toxicity of Tripterygium wilfordii Hook.f. with Triptolide as the Main Anticancer Bioactive Component

WANG Jun-ming, JIA Yu-mei, CUI Ying(School of Pharmacology,Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China)  
Objective To clarify the research progress and strategy in the toxicity of Tripterygium wilfordii Hook.f.with triptolide(TP) as the main anticancer bioactive component. Methods Looked through the related information and references from domestic and abroad,analyzed and reviewed them. Results Previous studies showed that the anticancer component TP isolated from T.wilfordii could induce hepatotoxicity,reproductive toxicity,cardiac toxicity,nephrotoxicity,anorexia,diarrhea,leanness,splenomegaly,atrophy of ovaries and so on.Furthermore,TP has narrow safety windows and thus may induce safety hazards. Conclusion We should carry out further studies on detoxification and enhancement actions by combination with other medicines so as to ensure its safety and validity in clinic application.Besides,the present paper may also provide the research guidance in thoughts for other toxic Chinese medicine.
【Fund】: 国家自然科学基金(No.30772794);; 河南中医学院博士科研基金(No.BSJJ2010-22)
【CateGory Index】: R285.5
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