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《Lishizhen Medicine and Materia Medica Research》 2012-04
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Effect of Extract of Cordyceps sinensis on Learning and Memory in Sodium Nitrite-treated Mice

GONG Mei-fang1, CHU Zhi-yong2, XU Jiang-ping1, LUAN Jie2, WANG Jia-chun2(Southern Medical University,Guangzhou 510515,China;2.Naval Medical Research Institute,Shanghai 200433,China)  
ObjectiveTo study the effect of extract of Cordyceps sinensis(Berk.)Sacc.(CSE) on learning and memory in sodium nitrite-treated mice and the possible mechanism. MethodsAn ICR mice model of the learning and memory disability was adopted by sc administering sodium nitrite(120mg/kg).The mice were fed with CSE 0.5,1,2g/kg or distilled water daily for two weeks.Step-down test and passive avoidence test were used to assess the memory ability of mice from the 13th day.Then the activities of SOD and GSH-Px and the concentration of MDA in serum were detected. ResultsThe ability of learning and memory was significantly improved by CSE as compared with the model group,the activities of SOD and GSH-Px were increased,and the concentration of MDA in serum was decreased in CSE treated groups. ConclusionCordyceps sinensis can significantly improve the learning and memory impairment in mice induced by sodium nitrite,and the mechanism may be related with the increased ability of anti-odidation.
【Fund】: 国家自然科学基金(No.30973518);; 中国人民解放军海军医学研究所基金(10HY21)
【CateGory Index】: R285.5
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