Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Lishizhen Medicine and Materia Medica Research》 2012-04
Add to Favorite Get Latest Update

Antidepressant Activities of Extracts from Gynostemma pentaphyllum(Thunb.) Makino

WANG Jun-ming, WANG Shuai, CUI Ying (School of Pharmacology,Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450008,China)  
ObjectiveTo investigate the antidepressant effect of extracts from Gynostemma pentaphyllum(Thunb.) Makino(Cucurbitaceae)(GP) for the first time. MethodsThree models,the mouse forced swim test(FST),tail suspension test(TST) and open field test(OFT),were used to observe antidepressant-like activity of the 75% ethanol extract(JE) and the water extract(JW) isolated from GP. ResultsCompared with the model group(CMC-Na),JE(2.5,5 g/kg,ig) significantly reduced the immobility time in dose-dependent manners during the FST and the TST,while JW(2.5,5 g/kg,ig) did not.Meanwhile,there was no significant difference between JE and fluoxetine hydrochloride(FH). ConclusionJE isolated from GP exerts antidepressant activity and has the similar effect with the positive drug FH,while JW dose not.
【Fund】: 国家自然科学基金(No.30772794);; 河南中医学院博士科研基金(No.BSJJ2010-22)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Xu Weilong1,Han Ning1,Wang Cuiling2(1.Weinan Municipal Mental Health Center,Weinan,Shaanxi,China 714000; 2.College of Life Sciences,Northwest University,Xi′an,Shaanxi,China 710069);Research Progress on Antidepressant-Like Effects of Active Ingredients of Natural Products[J];China Pharmaceuticals;2013-10
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SONG Shu-liang 1,2,TANG Jin-bao3,JI Ai-guo 1,2, LIANG Hao2, ZHU Peng1, WANG Wei-li2 (1.Pharmacy College of Shandong University, Jinan 250012, China; 2. Weihai International Biotechnology R & D Center, Weihai 264209, China; 3. Pharmacy Department of Weifang Medical College, Weifang 261042, China);The Extraction, Purification and Assaying of Gynostemma pentaphyllum Polysaccharides[J];Journal of Chinese Medicinal Materials;2006-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHENG Xiao-jiang et al (Key Laboratory of Biological Resources Protection and Utilization of Hubei Province,Research Institute of Biological Technology of Hubei Institutes for Nationalities,Enshi,Hubei 445000);Evaluation and Analysis for Content of Amino Acid in Sweet Gynostemma pentaphyllum Makino[J];Journal of Anhui Agricultural Sciences;2009-35
2 LU Ming-ming et al(School of Xingzhi,Nanjing Xiaozhuang University,Nanjing,Jiangsu 211171);Study on Anti-depressant Effect of Water Extract from Zhiqi Medicinal Fungal Substance[J];Journal of Anhui Agricultural Sciences;2011-18
3 WANG Yong-hengDa Xing Zhen Hospital,Hefei,Anhui 230011;The clinical application of medicine to agedness dementia[J];Journal of Anhui Health Vocational & Technical College;2004-05
4 ZHENG Li-fang,MING Liang(Department of Pharmacology,Anhui Medical University,Hefei,230032,China);The study and application of animal models of depression[J];Anhui Medical and Pharmaceutical Journal;2005-11
5 Lü Hang-zhou,Lü Ming-zhuang (Rehabilitation Department,the General Hospital of Xingtai Mining Industry Group, Hebei Xingtai 054000,China);Influence of Moxibustion on Changes of Behavior and Hormones of Hypothalamus-pituitary-adrenal Axis in Rats with Chronic Fatigue Syndrome[J];Journal of Anhui Traditional Chinese Medical College;2009-06
6 LI Qiu-bo~1,JIANG Sai-lin~2,YAO Di~1,ZHANG Ping~1,LI You-tian~,XU Cai-yun~3,XU Dan~1(1.Department of Traditional Chinese Medicine,First Hospital,Jilin University,Changchun 130021,China;2.Department of Operating Room,First Hospital,Jilin University,Changchun 130021,China;3.Department of Animal Experiment,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Effects of Shugan Jieyuling self-made on behavior and levels of serum IL-2,IL-6 and cortisol in depression models[J];Journal of Jilin University of (Medicine Edition);2005-06
7 YU Zhen,ZHANG Xiao-dong,CHEN Zhen,LIU Na-xin,DONG Qian-tong (Department of Surgery,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang,China);Establishment and assessments of a model of postoperative fatigue syndrome in rats[J];Parenteral & Enteral Nutrition;2009-02
8 HUANG Yue-dong,LI Bo,ZHAO Jun-fang(Xiamen TCM Hospital,Xiamen, Fujian 361001, China);Discussion on the Mechanism of Emotion Origination in TCM[J];Journal of Fujian College of Traditional Chinese Medicine;2004-04
9 Li Li, Ding Ni, Mei Leilei, Xue Feng, Dong Qi (Beijing Friendship Hospital, Beijing 100050) (Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875);A study of emotional processing in unipolar depression using fMRI[J];Chinese High Technology Letters;2007-12
10 CHEN Rui-ling, ZHAO Zhi-gang (Department of Pharmacy,Tiantan Hospital of Capital Medical University,Beijing 100050,China);Progress in clinical use of antidepressant[J];The Chinese Journal of Clinical Pharmacology;2007-01
China Proceedings of conference Full-text Database 6 Hits
1 Wang Qiang-Song Cui Yuan-Lu Ding Shi-Lan(Research Center of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193);Study on anti-inflammatory and antidepressant mechanisms of Zuojin Pill ethanol extracts(ZJP).[A];[C];2011
2 WANG Qian-dong 1,2,ZHU Jie-jin 1,ZHANG Lu 1,RUAN Li-na 1,PAN Jian-chun 1 (1.Department of pharmachology,Wenzhou Medical College,Wenzhou 325035 2.Department of Anesthesiology,People's Hospital of Ruian);Antidepressant like effect of acute administration with fisein combined with piperine and its possible mechanism[A];[C];2011
3 ;Antidepression Effect of polygala tenuifolia Willd[A];[C];2006
4 Zheng Xiaojiang~1,Xiang Dong-shan~1,Zhai Kun~2 1 Key Laboratory of Biological Resources Protection and Utilization of Hubei Province,Research Institute of Biological Technology of Hubei Institutes for Nationalities,Enshi Hubei,445000 2 College of Chemistry and Environment Engineering,Hubei Institute for Nationalities,Enshi Hubei,45000;Evaluation and analysis for content of amino acid in sweet Gynostemma pentaphyllum Makino'[A];[C];2009
5 Zhejiang Academy of Medical Sciences,Hangzhou 310013,China;Antidepression Effect of Baihedihuang Decoction[A];[C];2009
6 Wei Sheng,Liu Xin,Qiao Mingqi~* (Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry,Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Effect of Jingqianping Granule on expression of 5-HTR2C in rat cerebral cortex with anger emotion[A];[C];2012
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WU Yu,XIANG Xin-xin(Zhejiang province Wenzhou Third People′s Hospital Wenzhou 325000,China);Antidepressant effect of acute administration with Polyphenol extract from Zanthoxylum bungeanum maxim.and its possible mechanism[J];Strait Pharmaceutical Journal;2010-11
2 LU Hong,WU Yuexia,YANG Lijia,LI Jicheng,ZHANG Wei,LIU Na College of Pharmacy,Zhengzhou University,Zhengzhou 450001;Antidepressant effects of Citrus medica L.var.sarcodactylis swingle from Sichuan province[J];Journal of Zhengzhou University(Medical Sciences);2011-02
3 SHI Jin-cheng1,SUN Xing-hua2,LIU Yuan1,XIA Chao1,LIN Ben-qing2,FAN Ming2,ZHANG Gui-sen3,ZHANG Hui-yun4(1.Nanjing University of Technology,Jiangsu Provincial Institute of Materia Medica,Nanjing,Jiangsu,210009 P.R.China;2.Nanjing University of Technology,Nanjing,Jiangsu,210009 P.R.China;3.Jiangsu Nhwa Pharmaceutical Group Co.,Ltd.,Xuzhou,Jiangsu,221002 P.R.China;4.Shandong University of Traditional Chinese Medicine,Jinan,Shandong,250355 P.R.China);Study on antidepressant activity of different extracts from Hypericum wightianum[J];West China Journal of Pharmaceutical Sciences;2012-02
4 ZHENG Mei-zhu1,FAN Ya-jun2,XIU Jin3,SHI Dong-fang1,LIU Chun-ming1(1.The Central Laboratory,Changchun Normal University,Changchun 130032,Jilin,China; 2.The College of Life Science,Changchun Normal University,Changchun 130032,Jilin,China 3.High School Attached to Northeast Normal University,Changchun 130032,Jilin,China);Studies on the Antidepressant-Like Effect and 5-HT Mechanisms of Flavonoids Extracted from Apocynum venetum Leaves[J];Liaoning Journal of Traditional Chinese Medicine;2012-05
5 SHI Jin-cheng1,YAN Xian-guang1,LIU Yuan1,XIAO Chao1,ZHANG Hui-yun2,WEI Sheng2,LI Zi-fa2,QI Chao3,ZHANG Gui-sen3 (1.Nanjing University of Technology,Jiangsu Provincial Institute of Materia Medica,Nanjing 210009,Jiangsu,China;2.Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;3.Jiangsu Nhwa Pharmaceutical Group Co,Ltd,Xuzhou 221002,Jiangsu,China);Studies on Fractions with Antidepressant Activity from Hypericum Sampsonii Hance[J];Journal of Liaoning University of Traditional Chinese Medicine;2010-05
6 HU Guang-min1,ZHANG Zu-zhi1,PENG Qing-he2,QIN Yong2,SHEN Guo-ming2,XU Hao2(1 Department of Human Anatomy,Anhui University of Traditional Chinese Medicine,Hefei 230038,Anhui,China;2 Clinical College of Integrated Chinese and Western Medicine,Anhui College of Traditional Chinese Medicine,Hefei 230038,Anhui,China);Study on the Antidepressant-like Effect of Cimicifuga racemosa[J];Journal of Liaoning University of Traditional Chinese Medicine;2012-05
7 TONG Qian1,Corresponding author: LI You-lin2(1.Beijing University of Traditional Chinese Medicine,Beijing 100029,China; 2.Sino-Japanese Friendship Hospital,Key Laboratory of the State Administration of Traditional Chinese Medicine,Beijing 100029,China);Traditional Chinese Medicine Research and Analysis on The Treatment of Depression[J];Journal of Practical Traditional Chinese Internal Medicine;2011-04
8 FU Chun-yan1*,LIU Yong-hui2,LI Ming-juan1,WANG Xiao-hui1,YIN Wen-qing3 1Department of Pharmacy,Shaoyang Junior Medicine College;2Red Cross Hospital at Xinshao County of Hunan Province,Shaoyang 422000,China;3Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education of China,College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China;Extraction and Purification Techniques and Antidepression Activity of Total Saponins from Bulbs of Lilium brownii[J];Natural Product Research and Development;2012-05
9 TAO Zhen,LU Yi,SI Liang-hong,LU Yu,QIU Yan Department of Pharmacy,the No.454 Hospital of PLA,Nanjing 210002,China;Antidepression Action of Total Ginsenoside Extracts in Mice[J];Pharmaceutical and Clinical Research;2010-04
10 Yin Yongqin,Shen Zhibin(School of Traditional Chinese Medicinal Chemistry,Guangdong Pharmaceutical University,Guangzhou,Guangdong,China 510006);Research on Chemical Composition of Traditional Chinese Medicine Extraction Methods[J];China Pharmaceuticals;2012-02
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 TANG Xiao-jun, CHI Jian-wei, ZHANG Ming-wei, ZHANG Yan, LI Jian-xiong, WEI Zhen-cheng, ZHANG Rui-fen(Agro-biotech Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Food, Ministry of Agriculture, Guangzhou 510640, China);EXTRACTION CONDITIONS AND CONTENT DETERMINATION OF POLYSACCHARIDE IN LITCHI FRUITS[J];Journal of South China Normal University(Natural Science);2005-02
2 WANG Wei-guo,WU Qiang,HU Bao-kun,BAO Dong-wu,ZHAO Yong-liang 1.Biochemical Engineering Dept.,Nanyang Institute of Technology,Nanyang,Henan 473004,PRC.2.Medical School,Nanyang Institute of Technology,Nanyang,Henan 473002,PRC.3.Agricultural Dept.,Sichuan Agricultural University.Ya'an,Sichuan,625014,PRC.;Comparative Study on Determination Methods of Residual Protained in Grifolan[J];Edible Fungi of China;2003-01
3 Wang Linli,Wang Jiyue (Dept.of Pharmacy,Daping Hospitl,The Third Military Medical University,Chongqing 400042 China);Pharmacology Action and Progress In Clinic Application of Gynostemma Pentaphylum(Thumb) Mak[J];Information on Traditional Chinese Medicine;2002-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved