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《Lishizhen Medicine and Materia Medica Research》 2012-07
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Study on the anti-fatigue and hypoxia tolerance effect of Rosa roxburghii Tratt. extract in mice

XIA Xing1, ZHONG Zhen-guo1, LIAO Lin-zhi1, HE Wei-pin2(1.School of pharmaceutical Scievces Guangxi Univerty of Chinese Medicne,Guangxi Nanning 530001,China;2.Guilin JiQi Shili Natural Plant Science & Technology Co,Guangxi Guilin 541213,China)  
Objective To evaluate anti-fatigue and hypoxia tolerance effect of Rosa roxburghii Tratt.extract in mice. Methods Exhaustive swimming test and atmospheric hypoxia test were employed to evaluate anti-fatigue and hypoxia tolerance effect of Rosa roxburghii Tratt.extract orally administrated for 21 days consecutively.Furthermore,liver glycogen and muscle glycogen level were examined,and urea nitrogen level,lactic acid level and lactate dehydrogenase activity after swim were determined. Results Rosa roxburghii Tratt.extract extended swimming time at 2.0 g/kg and 1.0 g/kg(P0.01),extended hypoxia survival time at 0.5 g/kg(P0.05) significantly.Moreover,liver glycogen and muscle glycogen level were significantly increased after treatment(P0.05),urea nitrogen level,lactic acid level were decreased(P0.01). Conclusion Rosa roxburghii Tratt.extract enhance the anti-fatigue and hypoxia tolerance ability significantly,those activity could be mediated by increase glycogen reserve and improve aerobic glycolysis ability.
【Fund】: 广西壮族自治区自然科学基金创新研究团队项目(No.2011GXNSFF018006);; 广西中医药大学院级课题(No.P2009054)
【CateGory Index】: R285.5
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