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Anti-hypertensive Effect of Gpenosides in High-glucose-and-Fat-induced Hypertension in Rats

LIANG Xiao-hui, LI Wei-jian, CHEN Wen-pu, YANG Li-li, CHEN Zhi-ming, CHEN Li-xin, WENG Wen, ZHU Lin-yan(Department of Pharmacology,Medical College,Jinan University,Guangzhou 510632,China)  
Objective To investigate the anti-hypertensive effects of gypenosides(GPs) in high-glucose-and-fat-induced hypertension rats. Methods Rats were divided into 4 groups.Group A(control) were fed with normal food and orally administered with NS;Group B were fed with normal food and orally administered with medium dose of gypenosides.Group C were fed with food rich in glucose and fat and orally administered with NS.Group D were fed with food rich in glucose and fat and orally administered with three different(180,360,720 mg/kg) doses of gypenosides.After above treatment for 8 weeks the BL-420F biological system was used to measure the blood pressure. Results High-glucose-and-fat treatment induced the increase of rat blood pressure significantly.Compared with the control group,the systolic blood pressure was increased(35.1 ± 10.7)%,and the diastolic blood pressure was increased(18.1 ± 8.6)%(n=8,P0.01).Intervention with GPs was shown a dose-dependent effect against the elevated blood pressure induced by high-glucose-and-fat treatment.Acute administration of GPs by tail vein injection also decreased the blood pressure both in normal and hypertensive rats.However,the effects were much stronger in hypertensive rats than those in normal rats. Conclusion GPs can prevent the high-glucose-and-fat-induced hypertension in rats and has a relatively safe effect on treatment of hypertension.
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