Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Lishizhen Medicine and Materia Medica Research》 2012-10
Add to Favorite Get Latest Update

Anti-hypertensive Effect of Gpenosides in High-glucose-and-Fat-induced Hypertension in Rats

LIANG Xiao-hui, LI Wei-jian, CHEN Wen-pu, YANG Li-li, CHEN Zhi-ming, CHEN Li-xin, WENG Wen, ZHU Lin-yan(Department of Pharmacology,Medical College,Jinan University,Guangzhou 510632,China)  
Objective To investigate the anti-hypertensive effects of gypenosides(GPs) in high-glucose-and-fat-induced hypertension rats. Methods Rats were divided into 4 groups.Group A(control) were fed with normal food and orally administered with NS;Group B were fed with normal food and orally administered with medium dose of gypenosides.Group C were fed with food rich in glucose and fat and orally administered with NS.Group D were fed with food rich in glucose and fat and orally administered with three different(180,360,720 mg/kg) doses of gypenosides.After above treatment for 8 weeks the BL-420F biological system was used to measure the blood pressure. Results High-glucose-and-fat treatment induced the increase of rat blood pressure significantly.Compared with the control group,the systolic blood pressure was increased(35.1 ± 10.7)%,and the diastolic blood pressure was increased(18.1 ± 8.6)%(n=8,P0.01).Intervention with GPs was shown a dose-dependent effect against the elevated blood pressure induced by high-glucose-and-fat treatment.Acute administration of GPs by tail vein injection also decreased the blood pressure both in normal and hypertensive rats.However,the effects were much stronger in hypertensive rats than those in normal rats. Conclusion GPs can prevent the high-glucose-and-fat-induced hypertension in rats and has a relatively safe effect on treatment of hypertension.
【Fund】: 国家自然科学基金(No.31070997);; 暨南大学本科创新项目(No.cx11146)
【CateGory Index】: R259
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 6 Hits
1 CAI Ying,QI Chun-li,WU Duo,GAO Rui,Lü Jun-hua(Dept.of Pharmacology in College of Pharmacy,Jinan University,Guangzhou,Guangdong 510632,China);The protecting effects of berberine on the hypertensive renal impairment in rats fed by enriched high fat-salt-fructose diet[J];Journal of Guangdong Pharmaceutical College;2011-01
2 HUANG Ping,JIN Lijun,QIAN KangZhejiang Chinese Medical Hospital,Hangzhou(310006);The Effect of Gynostemma Pentaphylla Powder on the Renal Angiotension and Endothelin's expression in Diabetic Nephropathy Rats[J];Chinese Journal of Integrated Traditional and Western Nephrology;2009-09
3 OUYANG Jian-mei LONG Yuan FANG Ke-nan WANG Rui CHEN Qiang (College of Life and sciences,Lanzhou University,Lanzhou 730000,Gansu,China);Vasorelaxation Effects of Ethanol Extracts of Propolis(EEP) on Guinea Pig Thoracic Aorta[J];Progress in Modern Biomedicine;2007-09
4 YANG Xue-wei,GUO Yun-liang,CHONG Zhuo,CHEN Jun,JIAO Fu-feng.Institute of Cerebrovascular Diseases,Qingdao University Medical College,Qingdao 266003,China;Effect of Chinese Herb Sinitang (Monkshood,ginger and licorice) on Blood Pressure in Renovascular Hypertensive Rats[J];Chinese Journal of Hypertension;2007-03
5 TAN Hua-Bing,KUANG Yin-Wen.Affiliated People's Hospital of Yunyang Medical College,Shiyan 442000,Hubei,China;Comparision study on effects of gold theragran on microstructure and ultrastructure of aorta atherosclerosis in rabbits with hyperlipoidemia[J];Chinese Journal of Gerontology;2007-13
6 WANG Bei,WANG Chang-hai,TIAN Xin,et al Xijing Hospital of The Fourth Military Medical University(Xi'an 710032);The Influence of Juteng Capsule on Blood Pressure and Plasma Aldosterone and Catecholamine of Stress-induced Hypertension in Rats[J];Journal of Emergency in Traditional Chinese Medicine;2009-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Qiang1,XIE Hui-chen1,PAN Qing-hua2,LIU Xiao-qin3,XU Jian-hua1, ZHAO Xiao-qin1,JIANG Jin-lin1(1.Department of Traditional Chinese Medicine,Affiliated Hospital,Hubei University for Nationalities, Enshi 445000,China;2.Department of Digestive Medicine,Central Hospital,Enshi Autonomous Prefecture, Enshi 445000,China;3.Department of Preventive Medicine,Center for Disease Control and Prevention of Enshi,Enshi Autonomous Prefecture,Enshi 445000,China);Evaluation on curative effect of Self-prepared Softening Liver and Eliminating Fat Decoction in treatment of non-alcoholic steatohepatitis[J];Journal of Jilin University(Medicine Edition);2012-01
2 WANG Xiao-shun (Wuhu TCM Hospital, Wuhu 241000, China);Thinking of clinical research on efficacy of traditional Chinese antihypertensive drugs[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-04
3 HUANG Ping1,WANG Yan-qiu2(1Zhejiang Hospital of TCM,Hangzhou 310006,China;2Hangzhou Red Cross Hospital,Hangzhou 310003,China);Effect of gypenoside on the podocyte injury and its mechanism in rats with diabetic nephropathy[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-03
4 TIAN Xin,WANG Chang-Hai,LI Rui,MA Jing Department of Traditional Chinese Medicine,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Effect of Juteng Capsule on inflammatory factors of spontaneous hypertensive rats[J];Journal of the Fourth Military Medical University;2009-22
5 Yan Xiaochao1,Jiang Fan2,Lei Rei1,Peng Gongming1,Nie Yujing3(1.College of Chemistry Engineering and Technology,Wuhan University of Science and Technology,Wuhan 430081;2.College of Medicine,Wuhan University,Wuhan 430061;3.Department of Material Engineering,Hubei Automotive Industries College,Shiyan 442002,China);Research of Seven Kinds of Blood Pressure Lowering Chinese Traditional Medicine by FT-IR Spectra[J];Guangdong Chemical Industry;2010-11
6 PAN Zhi-hao1,YE Zhen-zhen2,CUI Sheng-miao2(1.Chencun Hospital of Shunde,Foshan 528313,China;2.School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China);Study on extraction process of total flavonoids from Gynostemma pentaphyllum[J];Journal of Guangdong Pharmaceutical University;2012-01
7 YOU Shu-mei,ZHU Yu-ting(Zhejiang Institute of Dermatology,Deqing 313207,China);Effect of Common Selfheal Fruit-Spike on blood pressure in spontaneously hypertensive rates[J];Strait Pharmaceutical Journal;2011-03
8 XU Yan-qin,HU Sheng-fu,LIU Yong,LAI Xue-wen,LIU Qing-hua,GE Fei(College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China);Investigation and Exploitation of Rare and Endangered and Rich Medicinal Plant Resources in Ganjiang River Source Nature Reserve of Jiangxi Province[J];Acta Agriculturae Universitatis Jiangxiensis;2010-06
9 YAN Xu,ZHANG Qi(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China);Research Situation and Outlook of Sini Decoction[J];Journal of Liaoning University of Traditional Chinese Medicine;2011-12
10 HUANG Rong(Department of Chemistry and Applied Chemistry,Chengdu Normal University,Chengdu 611130,China);Preparation technique of Compound Gynostemma pentaphyllum tablets[J];Pharmacy and Clinics of Chinese Materia Medica;2012-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 GE Jun,ZHU Yu-jie,WU Jun,YAO Bei-bei (Faculty of Clinical Medicine,Bengbu Medical College,Bengbu 233030,China);Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits[J];Journal of Bengbu Medical College;2006-04
2 WANG Xiuqing,GAO Zhen,GUO Hong,et al.Lab of Military Pathology,Bethune military Medical College,Shijiazhuang 050081,China;Creation of Chronic Stress Hypertension Animal Model[J];Journal of Bethune Military Medical College;2003-04
3 Zhao Zhi - gang, Liu Jing, Zhan Jian - qing, et al. (Department of Medical,the First Hospital of Shijiazhuang,Shijiazhuang 050011);Effects of Nifedipine Liberant on Endothelial Function and Intima - media Thickness of Carotid Arteries in Elderly Hypertensive Patients[J];Chinese Journal of Medicinal Guide;2002-05
4 Zhang Xiaoli Liu Zhen Zhu Ziping Yang Puzhao Xie Renming (Department of Pharmacology, Shanxi Academy of Traditional Chinese Medicine Xi'an 71003);INFLUENCE OF GYPENOSIDES ON THROMBUS AND COAGULATION FUNCTION IN VIVO AND IN VITRO[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1999-Z1
5 GUO Mi,WEI Qian,ZHANG Zhongjun,XU Shoushui,JIANG Ping(PLA 208 Hospital,Changchun 130062,China);Effects of anti-anoxia and anti-oxidation of Chinese herb drug puerarin[J];Journal of Health Care and Medicine in Chinese PLA;2007-02
6 GE Zhi\|hua 1* , WANG Chun\|yan\+2, LIU Hong\|yan\+1, ZHANG Jun\|chuan\+1, GAO Fu\|lu\+2 (1\^Department of Stomatology,Chengde Medical College,Chengde\ 067000; 2\^Department of Histology and Embryology,Chengde Medical College,Chengde\ 067000,China) \;[;EXPRESSION OF NGF IN SUBMANDIBULAR GLAND OF C57BL/ksj-db/db MUTANT DIABETIC MICE[J];Acta Anatomica Sinica;2002-06
7 ZHANG Yong,DING Guohua,ZHANG Jiane,et alDivision of Nephrology,The Affiliated Renmin Hospital of Wuhan University,Wuhan (430060);Effect of Gypenosides on Expression of Connective Tissue Growth Factor(CTGF) in UUO Rats with Renal Tubulointerstitial Fibrosis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2005-07
8 DUAN Bing-Nan,CHENG Qin-lin(Department of Histology and Embryology of XiangYa Medical College of Central South University,changsha 410013,China);Effects of Gypenosides on Enzyme Activity and Phagocytic Capacity of Peritoneal Macrophage in Mice[J];Acta Academiae Medicinae Jiangxi;2007-03
9 ZHANG Xiao-Ling1,XUE Bing1,LI Li1,CHEN Rong1,REN Dong-Mei2,LI Rui-Feng1,and HU Wei-Cheng1(1.School of Medicine;2.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China);Lobelia Chinensis Lour Alkaloids Inhibit Expression of Endothelin-1 mRNA and Protein in Renal Hypertensive Rats[J];Chinese Journal of Arteriosclerosis;2007-01
10 LI Shouwen LI Jing LIU Xiaohong JIN Yuzhen (College of Basic Medical Science Jiamusi University);The effects of Sinitang on the level of plasma tumor necrosis factor (TNF) in hemorrhagic shock in rabbts[J];Heilongjiang Medicine and Pharmacy;2002-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved