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《Lishizhen Medicine and Materia Medica Research》 2014-06
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Study on the effect of Polygonum multiflorum free anthraquinones extract on liver and renal function in rats with hyperlipidemia and acute toxicity

LIN Chang;YANG Chang-fu;WANG He-sheng;WANG Yong-long;YAO Ruo-wei;RUO Jie;WANG Yu-lin;Guiyang College of Traditional Chinese Medicine;  
Objective To discuss acute toxicity of processed products of Radix Polygoni Multiflori free anthraquinones extract to maximum tolerance to KM mice after intragastric administration of animal production,and further study of its effect on liver and kidney function in hyperlipidemic SD rats.Methods Radix anthraquinone in a given maximum tolerance dose of mice,the spontaneous activity of mice were observed for 30 min,120 min,420 min and 14 d body weight change,survival rate.By feeding high fat diet and fat emulsion duplicate the model of hyperlipidemia rats,for 2 weeks.After the model was made,were randomly divided into four groups: normal group,rats model group,free anthraquinone( 40 mg kg-1) the treatment was administered for 4weeks.Rats without any treatment in a week,detection of serum alanine aminotransferase( ALT),aspartate aminotransferase( AST) and serum creatinine( CREA).Results The free anthraquinone in Polygonum multiflorum in experimental acute toxicity in mice body weight in model group and control group had no significant difference( P 0.05).Radix Polygoni Multiflori free anthraquinones extract treatment group can significantly reduce the content of hyperlipidemia rats serum of ALT,AST increased because of liver cell damage cause.Conclusion Under the condition of this experiment Shouwu free anthraquinone in LD50more than 8000 mg·kg-1.The processing Polygonum multiflorum can reduce hyperlipidemia AST rats to normal levels,liver and kidney toxicity was not found.
【Fund】: 国家自然科学基金(No.81160418);; 贵州省科技厅贵阳中医学院联合基金(No.黔科合中药字[2010]LKZ7019号);; 贵州省科技英才青年培养工程项目(N为o.黔省专合(2012)0165号)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 7 Hits
1 ZHAI Rong LV Li-shuang JIN Bang-quan(Department of Food Science,Ginling College,Nanjing Normal University,Nanjing,Jiangsu210097,China);Hypolipidemic effect of the polysaccharide from polygonum multiflorum[J];Food & Machinery;2010-05
2 Xiang Congkun1,Wang Rui2,Yuan Zhifang3 (1.Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,China 050011;2.Chinese Medicine Diagnostic Teaching and Research Office,College of Chinese Medicine,Hebei Medical University,Shijiazhuang,Hebei,China 050091;3.Pharmaceutical College,Hebei Medical University,Shijiazhuang,Hebei,China 050017);Study on Effect of Polygonum Mutiflorum Extract on Lipid Metabolism and Its Anti-Oxidation in SD Rats with Hyperlipemia[J];China Pharmaceuticals;2009-24
3 YU Jie1,XIE Jie1,ZHAO Rong-hua1,CAI Shao-qing2,CHEN Zhen3 (1.Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;2.State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China;3.Yunnan Baiyao Group Co.,Ltd.,Kunming 650118,China);Advances in studies on liver adverse reaction of Polygonum multiflorum[J];Chinese Traditional and Herbal Drugs;2010-07
4 YU Jie,XIE Jie,MAO Xiao-Jian,WEI Hua,ZHAO Sheng-Lan,MA Ya-Ge,LI Na,ZHAO Rong-Hua * The Key Modern Research Laboratory for Ethno-pharmacognosy of Yunnan Higher School,Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Comparison of laxative and antioxidant activities of raw,processed and fermented Polygoni Multiflori Radix[J];Chinese Journal of Natural Medicines;2012-01
5 Zhao Jinming,Zhu Jinghe,Chen He,Qin Wenyan,Qi Yue,Li Guoxin (Liaoning Institute of Traditional Chinese Medicine,Shenyang 110034);Study of hyperlipidemia model in rats on different fat emulsion[J];Pharmacology and Clinics of Chinese Materia Medica;2012-01
6 GONG Yan-sheng1 ZHANG Ya-nan2 HUANG Wei1 SUN Hu1 SUN Rong1(1Shandong Research Academy of TCM,Shandong Jinan 250014,China;2Shandong University of Traditional Chinese Medicine,Shandong Jinan 250355,China);Research Development on Chemical Compositions of Polygonum Multiflorum Related to Efficacy and Toxicity[J];Chinese Journal of Pharmacovigilance;2012-08
7 CHEN Chao-yong,YAN Zhi-yong*,LI Shao-hua,CHEN Chong,ZUO Chang-ying(School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China);Effect of the Extract of Valeriana jatamansi on the Blood Lipid and Liver Function in Experimental Hyperlipidemia Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2012-19
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yun haixia Shu xiaohe Xiong zengfang Hou yongfang (College of Geography and Life Science,Qinghai Normal University,Xining,810008,China);Recearch Overview of Gentiana of Chinese herbal medicines[J];Anhui Agricultural Science Bulletin;2007-21
2 ZHAO Yu-cong et al(Department of Pharmaceutical Engineering,Zhengzhou College of Animal Husbandry Engineering,Zhengzhou,Henan 450011);Effects of Processing on the Activated Pharmaceutical Ingredients from Cornus officinalis[J];Journal of Anhui Agricultural Sciences;2008-35
3 WANG Chun-lan et al (Jilin Agricultural Sciences and Technology College,Jilin,Jilin 132101);Study on Effects of Different Harvesting Stage on Yield and Quality of Polygonatum odoratum[J];Journal of Anhui Agricultural Sciences;2009-05
4 YANG Hai-ling et al(Guangxi Traditional Chinese Medical University,Nanning,Guangxi 530001);Effects of Different Processing Methods on the Geniposide Content in FRUCTUS GARDENIAE[J];Journal of Anhui Agricultural Sciences;2011-32
5 Qian Suqing,Song Hongchun,Wang Dongna;Ethanol extraction process of Qiguifuzheng granules optimized with orthogonal experiment[J];Journal of North Pharmacy;2010-01
6 ZHANG Chunhong1,WANG Zheng2,ZHANG Lianxue2(1.Baotou Medical College,Baotou 014060,China 2.Academy of Chinese Traditional Medicine,Jilin Agricultural University);Determination of Magnoline in Both Raw Aristolochia Contorta and Honey-processed One by UPLC-MS/MS[J];Journal of Baotou Medical College;2012-01
7 LI Jin-lian,HU Chang-jiang(Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China);Comparison of fingerprints of semen trigonellae before and after stir-heated with salt solution[J];Journal of Chengdu Medical College;2009-03
8 LUO Huan-feng1,HU Chang-jiang1,LEI Yu2,WANG Xia2 (1.Chengdu University of TCM,Chengdu 611173,China;2.Hainan Coconut Island(Group)Co.,Ltd,Haikou 570102,China);Comparative study of sea snakes and its deodorized product after fermentation[J];Journal of Chengdu Medical College;2010-01
9 HE Yao,HU Hui-ling,FU Chao-mei,et al(school of pharmacy,TCM of chengdu university,Chengdu 610075,China);Comparative Study on Quality of Differently Processed Products of Radix Vldaimiriae[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-01
10 HE Zhong-Mei1,2,SUN Jia-Ming2,ZHANG Hui2,WANG Hua3 1(College of Chinese Medicine Materials,Jilin Agricultural University,Changchun 130117)2(Development Center of Traditional Chinese Medicine and Bioengineering,Changchun University of Traditional Chinese Medicine,Changchun 130117)3(College of Pharmaceutical Sciences,Harbin University of Commerce,Haerbin 150000);Analysis of Components in Aqueous of Paeonia Lactiflora Pall and Paeonia Lactiflora Pall Preparation with Wine by Solid Phase Extraction-High Performance Liquid Chromatography-Electrospray Ionization Mass Spectrometry[J];Chinese Journal of Analytical Chemistry;2009-08
China Proceedings of conference Full-text Database 5 Hits
1 SUN Jiaming1,ZHANG Hui (Development Center of Traditional Chinese Medicine and Bioengineering,Changchun University of Traditional Chinese Medicine,Changchun 130117,China);Analysis of Components in the Aqueous of Glycyrrhiza Uralensis Fisch.and Glycyrrhiza Uralensis Fisch.Preparated with Honey by SPE-HPLC-ESI/MS/MS[A];[C];2009
2 ;Comparative Study on the quality of differentlyprocessed products of Radix vldaimiriae[A];[C];2008
3 Jiaming SUN,Hui ZHANG (Development Center of Traditional Chinese Medicine and Bioengineering,Changchun University of Traditional Chinese Medicine,Changchun,130117,China);Analysis of Components in the Aqueous of Glycyrrhiza uralensis Fisch.and Glycyrrhiza uralensis Fisch. Preparated with honey bv SPE-HPLC-ESI/MS/MS[A];[C];2009
4 ;浅谈中药饮片调剂与处方应付[A];[C];2011
5 TANG Kun,Li Biao (.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100193,China);Optimization research of Processing methods onTibetan Herb Lamiophlomis rotata Kudo.[A];[C];2012
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Yuan Zhao kai et al (Hunan College of TCM);Relationship Between Phlegm-Blood Stasis Syndrome of Hyperlipemia and Insulin-resistance[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-08
2 NG Kit-ying, CHENG Chuen-lung, XU Hong-xi Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China;Safety Issues of Chinese Medicine:A Review of Intoxication Cases in Hong Kong[J];中草药(英文版);2009-01
3 FAN Li-lin,CHEN Dong-feng(Department of Gastroenterology,Daping Hospital,Third Military Medical University,Chongqing 40038,China);Effect of structural and functional damages in hepatic mitochondria on genesis of NAFLD[J];Chongqing Medicine;2007-15
4 SHAN An-shan,XU Qi-you (Animal Nutrition Institute,Northeast Agricultural University,Harbin Heilongjiang 150030,PRC);Animal lipid metabolism and regulation[J];Journal of Northeast Agricultural University;2004-02
5 Chen Wansheng,Fan Wei,Yang Genjin,Qiao Chuanzhuo,Chen Haisheng,Yuan Yuan(Department of Pharmacognosy, College of Pharmacy,Second Military Medical University,Shanghai, 200433);Studies on the chemical constituents of Radix Polygoni multiflori Preparata[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-07
6 Cai Kun,Feng Hua,Tian Weiyi(Guiyang College of TCM,550002,Guiyang,China);Effects of pure breed fermentation on major effective component in semen sojae praeparatum[J];Journal of Gansu College of Traditional Chinese Medicine;2006-05
7 Wei Ping(Hospital for Staffs and Workers,Pingdingshan Tianhong Coke Company,Pingdingshan Henan,467021);Laboratory study of Shanhe Capsule on Reducing Blood Lipid in Hyperlipemia Model Rats[J];World Journal of Integrated Traditional and Western Medicine;2009-01
8 Hu Xiqin Yang Honglian Zhang Xiaoqin Miao Yanxia Geng Zengyan(Shaanxi University of TCM Xian yang,Shaanxi 712046);Experimental Study on the Toxicology ofPrepared Radix Polygoni Multiflori to the Rats' Liver[J];Journal of Shaanxi College of Traditional Chinese Medicine;2006-03
9 Hu Xiqin1,Fang Huanle1,Quan Zhibo1,Geng Zengyan2(1.Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712083;2.North China Coal Medical University,Tangshan,Hebei,063000);Experimental Study of Radix Plygonl Mltiflori Peparata on Liver's Biochemical Matters[J];Journal of Shaanxi College of Traditional Chinese Medicine;2007-06
10 ZHAO Rong-hua,ZHAO Sheng-lan,MAO Xiao-jian,XIE Feng-jiang,LIU Zhen-zhen(Research Center of Chinese Mdeica Processing,Yunnan University of Traditional Chinese Medicine,Kunming,650200,China);Study on the Correlationship between the Content of Combined Anthraquinone and Purgative Action of Steamed Polygonum Multiflorum Thunb.[J];Lishizhen Medicine and Materia Medica Research;2008-11
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