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《Lishizhen Medicine and Materia Medica Research》 2014-06
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Study on the effect of Polygonum multiflorum free anthraquinones extract on liver and renal function in rats with hyperlipidemia and acute toxicity

LIN Chang;YANG Chang-fu;WANG He-sheng;WANG Yong-long;YAO Ruo-wei;RUO Jie;WANG Yu-lin;Guiyang College of Traditional Chinese Medicine;  
Objective To discuss acute toxicity of processed products of Radix Polygoni Multiflori free anthraquinones extract to maximum tolerance to KM mice after intragastric administration of animal production,and further study of its effect on liver and kidney function in hyperlipidemic SD rats.Methods Radix anthraquinone in a given maximum tolerance dose of mice,the spontaneous activity of mice were observed for 30 min,120 min,420 min and 14 d body weight change,survival rate.By feeding high fat diet and fat emulsion duplicate the model of hyperlipidemia rats,for 2 weeks.After the model was made,were randomly divided into four groups: normal group,rats model group,free anthraquinone( 40 mg kg-1) the treatment was administered for 4weeks.Rats without any treatment in a week,detection of serum alanine aminotransferase( ALT),aspartate aminotransferase( AST) and serum creatinine( CREA).Results The free anthraquinone in Polygonum multiflorum in experimental acute toxicity in mice body weight in model group and control group had no significant difference( P 0.05).Radix Polygoni Multiflori free anthraquinones extract treatment group can significantly reduce the content of hyperlipidemia rats serum of ALT,AST increased because of liver cell damage cause.Conclusion Under the condition of this experiment Shouwu free anthraquinone in LD50more than 8000 mg·kg-1.The processing Polygonum multiflorum can reduce hyperlipidemia AST rats to normal levels,liver and kidney toxicity was not found.
【Fund】: 国家自然科学基金(No.81160418);; 贵州省科技厅贵阳中医学院联合基金(No.黔科合中药字[2010]LKZ7019号);; 贵州省科技英才青年培养工程项目(N为o.黔省专合(2012)0165号)
【CateGory Index】: R285.5
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