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《Lishizhen Medicine and Materia Medica Research》 2014-09
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Peimisine attenuates acute lung injury induced by lipopolysaccharide in mice

CUI Yan ru;LIU Hai-yun;QU Fei;Department of Physiology,Jiangxi University of Traditional Chinese Medicine (TCM);Department of Pharmacology,Jiangxi University of TCM;  
Objective To determine the protective effect of Peimisine on acute lung injury( ALI) induced by lipopolysaccharide( LPS) and its protective mechanism mice. Methods The mice were randomly allocated into sham,LPS and Peimisine + LPS groups. The ALI mice was induced by LPS after etherization. The Peimisine was injected by belly cavity 30 minutes prior to the LPS challenge,one time/d,3 times totally. The mice were killed 24h after the third Peimisine injection to observe the amount of LDH,MDA in plasma,the lung tissue pathology,the total protein,white blood cell and differential count in the bronchoalveolar lavage fluid( BALF). Results LDH,MDA amount in plasma,Lung tissue,and BALF showed serious inflammatory changes in the LPS group. Compared with the LPS group,Peimisine attenuates Lung tissue injury,LDH and MDA amount in ALI mice in a dose dependent manner. Peimisine( 0. 12mg) lowered the total protein,total white blood cells,lymphocyte and neutrophilic leukocyte in BALF compared with the LPS group. Conclusion Peimisine can play a protective role against LPS-induced acute lung injury.
【Fund】: 江西省卫生厅中医药科研基金(No.2012A151);; 江西中医药大学重点学科基金和江西中医药大学道地药材专项基金
【CateGory Index】: R285.5
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