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《Lishizhen Medicine and Materia Medica Research》 2014-10
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Effect of polydatin on vasodilation of rat isolated thoracic aortas

WU Yang;HUANG Bo;YANG Xin;XUE Lai;GAO Li-jia;JIANG Qing-song;Department of Pharmacology,Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology,Chongqing Medical University;Experimental Teaching Center,Chongqing Medical University;  
Objective To investigate the effect of polydatin( PD) on isolated vascular smooth muscle tension and to explore the mechanisms of PD. Methods The isolated thoracic aortic rings of Sprague Dawley rats were mounted in the organ bath and tension was recorded by BL-420 S biological signal assay system. The rings with endothelium-intact or endothelium-denuded were pre-contracted by phenylephrine( PE,10-6mol /L),and the effect of PD on the vessel reaction induced by various drugs were recorded. Results PD( 1 × 10-9~ 3 × 10-4mol /L) relaxed the contractions induced by PE in a concentration-dependent manner in endothelium-intact aortic rings,the maximum relaxation effect and-log IC50 are 79. 75% ± 8. 34% and 6. 13 ± 1. 55,respectively. However,PD could not inhibit the contraction in endothelium-denuded aortic rings,the maximum relaxation effect and-log IC50 lowed to 11. 15% ± 2. 89% and 0. 47 ± 2. 96,respectively( P 0. 05). The vasodilative effect of PD was significantly reduced by GSK0660( PPARβ blocker,10-6mol /L),PDTC( NF-κB blocker,10-6mol /L) or L-NAME( NOS inhibitor,10-5mol / L) in endothelium-intact aortic rings( P 0. 05),but was not inhibited by meloxicam( COX-2 inhibitor,10-6mol /L)( P 0. 05). Conclusion These results indicate that PD possesses the endothelium-dependent relaxation which is probably,at least partly,related to PPARβ and /or NF-κB signal transduction pathways,promoting the release of nitric oxide,but prostacyclin is not involved in PD-induced vasodilatation.
【Fund】: 国家自然科学基金(No.81100905);; 重庆医科大学大学生科学研究与创新实验资助项目(No.201328)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 HUANG Hai-liang Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pharmacological Progress of HuZhang[J];Western Journal of Traditional Chinese Medicine;2012-04
2 LIU Yin-hua,SHEN Jie,AI Wen-li(Medical College of Shaoguan University,Shaoguan,512026,China);Effect of Huzhang on the Isolated Guinea-Pig Heart and Rabbit Vascular Smooth Muscle[J];Lishizhen Medicine and Materia Medica Research;2008-08
3 WANG Jun,FANG Fang.(Department of Pharmacology of Chinese Medicine College,Beijing University of Chinese Medicine,Beijing 100102,China);Progress in Pharmacological Study of Polydatin in Cardio-cerebrovascular System[J];Medical Recapitulate;2012-13
4 RU Xiao-chen,QIAN Ling-bo,CUI Jie,QIAN Yun,GAO Qin,XIA Qiang(Department of Physiology,Zhejiang University School of Medicine,Hangzhou 310058,China);VASODILATING EFFECT AND ITS MECHANISM OF ETHANOL ON ISOLATED RAT THORACIC AORTA AT DIFFERENT RESTING TENSION[J];Chinese Journal of Applied Physiology;2008-03
5 FAN Hui-ting,DING Shi-lan,LIN Hong-sheng(Oncology Department of Guang'anmen Hospital of China Academy of traditional Chinese medicine,Beijing 100053,China);Pharmacological of Polygoni Cuspidati Rhizoma[J];China Journal of Chinese Materia Medica;2013-15
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Yong-An YANG Fa-Cheng~a SI Min-Zhen (Department of Physics and Electronic Science,Chuxiong Normal University,Chuxiong,Yunnan 675000,P.R.China) a(Chuxiong Institute of Traditional Chinese Medicine,Chuxiong,Yunnan 675000,P.R.China);Study on Four Kinds of Drugs for Invigorating Blood Circulation by FTIR Spectrometry[J];Chinese Journal of Spectroscopy Laboratory;2009-05
2 HUANG Hai-liang Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pharmacological Progress of HuZhang[J];Western Journal of Traditional Chinese Medicine;2012-04
3 DUAN Yu-lin1,MO Feng-wen3,CHEN Zhen-hua1,SU Jun1,ZHANG Shao-mei2(1.Guangxi Product Quality Supervision and Inspection Research Institute,Nanning 530007,China; 2.Guangxi Environmental Protection Monitoring Central Station,Nanning 530022,China; 3.Baise Bureau of Quality and Technical Supervision,Baise 533000,China);Determination of 28 elements in Polyonum cuspidatum by ICP-MS[J];Journal of Guangxi University(Natural Science Edition);2012-06
4 TAN Peng1,PU Xu-feng2,LUO Xiao2(1.Chengdu University of TCM,Chengdu,611137,China;2.Institutute for Food and Drug Quality Control of chengdu,Chengdu,610045,China);Determination of Content of Polydatin in Hu-Huang-Shao-Shang Linimentum with High Performance Liquid Chromatography[J];Journal of Chengdu University of Traditional Chinese Medicine;2013-01
5 ZHU Tong-tong;LIN Gui-miao;FAN Wen-jing;LIU Guang-yao;ZHAO Li-hua;ZHAO Li-jing;ZHAO Li-juan;Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University;Department of Orthopedics,China-Japan Union Hospital,Jinlin University;Urinary and Reproductive Center,School of Medical Science,Shenzhen University;Department of Basic Nursing,School of Nursing,Shanghai Traditional Chinese Medical University;;Expressions of Bcl-2 and Bax in hippocampal neurons of senile mice with cervical vertebral instability[J];Journal of Jilin University(Medicine Edition);2013-05
6 WANG Fan;NI Qing;Endocrinology department,Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Beijing University of Traditional Chinese Medicine;;Advances in TCM treatment of disorders of lipid metabolism[J];Journal of Changchun University of Traditional Chinese Medicine;2014-03
7 ZHANG Jianxing;LI Hongying;ZHOU Guobin;WANG Qing;LI Zhen;Department of Anesthesiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences;;Changes of platelet mitochondria in rats with tourniquet- induced limb ischemiareperfusion injury[J];Journal of Southern Medical University;2014-07
8 WANG Hui-zhu,YU Jiang-tao*,ZHANG Chuang*(College of Chemical & Pharmaceutical Engineering,Jilin Institute of Chemical Technology,Jilin city 132022,China);Optimization of the Extraction Processfor Resveratrol from Polygonum cuspidatum stem by Orthogonal Design[J];Journal of Jilin Institute of Chemical Technology;2013-03
9 FU Guo-tong;YU Xue-li;ZHANG Xin;WANG Nan;PIAO Xian-mei;College of Pharmacy,Harbin Medical University;College of Traditional Chinese Pharmacology,Yunnan University of TCM;;Polydatin,a extract from Hydrangea: antiarrhythmic and anti-myocardial ischemia efficacy[J];Journal of Harbin Medical University;2013-06
10 LIU Dan-lu;LIN Yong-jun;National Key Laboratory of Crop Genetic Improvement/National Center of Plant Gene Research (Wuhan) ,Huazhong Agricultural University;;Transforming rice (Oryza sativa L.) with a Vitis stilbene synthase gene[J];Journal of Huazhong Agricultural University;2014-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SONG Kang1,LUO Xian-fang1,YANG Jun-chao1,XIA Yong-liang1,SHI Yajie2,LI Bo-ying3(1Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310006,China;2 Hangzhou Hospital ofTraditional Chinese Medicine,Hangzhou 310006,China;3Honghui Hospital of Hangzhou,Hangzhou 310009,China);Effect of Rhizoma Polygoni Cuspidati on expression of TGF-β_1 in rats with pulmonary fibrosis[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-12
2 SONG Junhua1 WANG Shuyun2 MU Daoyu2 et al1 Qingdao Health School,Qingdao 266071;2 School of Medicine,Shandong University;Effect of polydatin monomer on acute viral myocarditis[J];Journal of Binzhou Medical University;2008-02
3 Luo Sufang, Zhang Peiwen,Li Ruisong Department of Pharmacology, First Military Medical University;Dilating action of 3 , 4', 5 - trihydroxystibene - 3 -β -mono-D-glucoside on rabbit' s blood vessels[J];Journal of First Military Medical University;1992-01
4 Liu Lianpu; Shan Chunwen; Liu Xihong;Xiao Huancai;Yang Shuqin; An Lianbing (Department of Electron Microscopy, Department of Pharmacology, First Military Medical University,Guangzhou, 510515; Department of Electron Microscopy,Guangzhou Medical College,Gua;Effects of Polydatin on the ultrastructure of platelets[J];Journal of First Military Medical University;1998-02
5 HUANG Hai-xiao, ZHAO Qing, JIN Chun-hua Key Laboratory of Microcirculation of PLA, First Military Medical University, Guangzhou 510515, China;Effect of polydatin on lipopolysaccharide-induced leucocyte chemotaxis[J];Journal of First Military Medical University;2003-12
6 XU Bing, LIN Huan-bing, ZHOU Heng, Xu Jiang-ping Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;Protective effect of polydatin on a PC12 cell model of oxygen-glucose deprivation[J];Journal of Southern Medical University;2010-05
7 Jin Chunhua,Zhao Kesen Deparmtnet of Pathophysiology,First Military Medical University,Guangzhou,510515;The effect of Polydatin on membrane potential of cultured vascular smooth muscle cells of rat[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1998-03
8 SHU Shiyu(Children's Hospital, Chongqing University of Medical Sciences, Chongqing 400014);The biologic activity and pharmacology effect of polydatin[J];Journal of Pediatric Pharmacy;2002-01
9 WANG Yue-gang,SUN Zhu-Hua,PEI Jing-Xian,JIN Chun-hua. Department of Cardiology,NanFang Hospital,Southern Medical University.GuangZhou 510515,China;Effects of Polydatin on Production of Nitric Oxide in Pulmonary Endothelial Cells[J];Guangdong Medical Journal;2010-08
10 ;Effect of NAFLD rats intervened by the e xtracts of rizoma polygoni cusp idati[J];Guangzhou Medical Journal;2005-03
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