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《Lishizhen Medicine and Materia Medica Research》 2014-10
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Effect of polydatin on vasodilation of rat isolated thoracic aortas

WU Yang;HUANG Bo;YANG Xin;XUE Lai;GAO Li-jia;JIANG Qing-song;Department of Pharmacology,Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology,Chongqing Medical University;Experimental Teaching Center,Chongqing Medical University;  
Objective To investigate the effect of polydatin( PD) on isolated vascular smooth muscle tension and to explore the mechanisms of PD. Methods The isolated thoracic aortic rings of Sprague Dawley rats were mounted in the organ bath and tension was recorded by BL-420 S biological signal assay system. The rings with endothelium-intact or endothelium-denuded were pre-contracted by phenylephrine( PE,10-6mol /L),and the effect of PD on the vessel reaction induced by various drugs were recorded. Results PD( 1 × 10-9~ 3 × 10-4mol /L) relaxed the contractions induced by PE in a concentration-dependent manner in endothelium-intact aortic rings,the maximum relaxation effect and-log IC50 are 79. 75% ± 8. 34% and 6. 13 ± 1. 55,respectively. However,PD could not inhibit the contraction in endothelium-denuded aortic rings,the maximum relaxation effect and-log IC50 lowed to 11. 15% ± 2. 89% and 0. 47 ± 2. 96,respectively( P 0. 05). The vasodilative effect of PD was significantly reduced by GSK0660( PPARβ blocker,10-6mol /L),PDTC( NF-κB blocker,10-6mol /L) or L-NAME( NOS inhibitor,10-5mol / L) in endothelium-intact aortic rings( P 0. 05),but was not inhibited by meloxicam( COX-2 inhibitor,10-6mol /L)( P 0. 05). Conclusion These results indicate that PD possesses the endothelium-dependent relaxation which is probably,at least partly,related to PPARβ and /or NF-κB signal transduction pathways,promoting the release of nitric oxide,but prostacyclin is not involved in PD-induced vasodilatation.
【Fund】: 国家自然科学基金(No.81100905);; 重庆医科大学大学生科学研究与创新实验资助项目(No.201328)
【CateGory Index】: R285.5
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