Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Reproductive Medicine》 2001-03
Add to Favorite Get Latest Update

The effect of estrogen-like drug on the cognition of ovariectomized rats

ZHANG Xiao chun, ZUO Ping ping, GE Qin sheng * Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005 *Department of Obsterics & Gynecology, Peking Union Medical College Hospita  
To observe the effects of estrogen and NH1996 on cognition and neurochemical changes including central cholinergic, glutamatergic and monoaminergic systems in brain of adult ovariectomized (OVX) rats. Methods: Behavioral study and neurochemical study were used. Results: In OVX group, the behavioral study examing passive and active avoidance tasks showed that learning and memory capability was weakened. Neurochemical study showed that choline acetyltransferase (ChAT) activity in the cerebral cortex and hippocampus decreased significantly; the specific binding of 3H QNB for m ACh receptor(m AChR) activity and 3H MK801 for N methyl D aspartate receptor (NMDAR) in the cerebral cotrex decreased significantly; while the activity of monoamine oxidase B(MAO B) increased. After treating with EB or NH1996 at a dosage of 200 μg per rat, im, once every three days, for six weeks, all changes mentioned above were reversed. Conclusions: EB and NH1996 take part in the regulation of learning and memory through cholinergic, glutamatergic and monoaminergic mechamisms.
【Fund】: 国家科技部重点 973项目! (基金编号 :J2 0 0 0 5 710 0 8)
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved