Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Reproductive Medicine》 2002-03
Add to Favorite Get Latest Update

Effects of estrogen on the central nigral-striatal dopamine neuron system in ovariectomized rats

ZUO Ping-ping, SUI Ya-ping, GE Qin-sheng * Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005 *Department of Obsterics & Gynecology, Peking Union Medical College Hospital, Beij  
Objective: To study the changes of content, release and receptor binding activity of striatum dopamine (DA) in ovariectomized (OVX) Wistar rats, and further investigate the effects of estrodial-17 β on the dopamine release of striatum slices in vitro. Methods: The content of DA was determined with HPLC-ED. Its release and receptor binding activity were measured with radioactivity assay. Results: The content of DA decreased significantly in OVX rats, but there was no change in its uptaking. The receptor activity increased 2 times in OVX rats as compared with the control group.The effect of estrodial-17 β on the DA release of striatum slices in vitro showed in bell-shaped dose-response curve.Conclusion: Estrogen could regulate the function of striatum dopamine neuron, and this action was site and dose dependent.
【Fund】: 国家科技部重点 973项目 (J2 0 0 0 5 710 0 8)
【CateGory Index】: R742.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved