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《Modern Medical Journal》 2011-05
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Histological observation of pravastatin intervention of rabbit femoral head necrosis induced by hormone

WANG Tao (Department of Anatomy,Medical College Affiliated to Wuhan University of Science and Technology,Wuhan 430065,China)  
Objective: To study the effect of pravastatin on tissue of rabbit femoral head necrosis induced by hormone.Methods: Twenty-four experimental rabbits were randomly divided into 3 groups,eight rabbits in ever group.Treatment group: pravastatin was used by gavage treatment after models were constructed by hormone;models group: saline was used by gavage treatment after models were constructed by hormone;control group: saline was used by gavage treatment.The changes of femoral heads tissue in 3 groups were observed.Results: Compared with the models group,the number and diameter of capillaries,percentage of vacant lacuna in treatment goup improved significantly(P0.05).Conclusion: Pravastatin has a good effect on the femoral head necrosis in rabbits induced by hormone.
【CateGory Index】: R681.8
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