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Study on the Pharmacokinetics of Metronidazole in Human Milk by Capillary Electrophoresis

LU Hao _ jie, ZHANG Hong, RUAN Zong _ qin, OU Qing _ yu(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China)  
The determination of metronidazole in human milk by capillary electrophoresis is reported. The method can also be employed for pharmacokinetic studies. After single vein injection of 1.25 g metro_nidazole, human milk samples were collected within 24 hours. With chloroform as the extraction solvent, the extraction recovery was found to be in the range from 90% to 101%. To decrease the detection limit, sample _ stacking injection was employed. Samples with tinidazole as an internal standard in 40 mmol/L Tris-phosphate buffer(pH 2.0) were analyzed. The linearity for metronidazole against the internal standard was given to be in the range of 0.40~25.67 mg/L, and the correlation coefficient r was greater than 0.999. The limit for quantification was 0.40 mg/L, whereas the detection limit(S/N=3) was 0.15 mg/L. The relative standard deviation(RSD) of repeatability for corrected metronidazole peak area against the internal standard was 1.5%. The method was used to get pharmacokinetic parameters with the aid of the computer program MCPKP.
【Fund】: 国家自然科学基金!资助项目 (29875033)
【CateGory Index】: O657.8
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