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《Journal of Instrumental Analysis》 2009-04
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Determination of Clindamycin by Using Enhanced Ru(bpy)_3~(2+) Electrochemiluminescence

LAN Su-mei1,LI Li-jun2,CAI Zhuo1,CHENG Hao2,CHEN Chang-dong1 (1.College of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China;2.Department of Biological and Chemical Engineering,Guangxi University of Technology,Liuzhou 545006,China)  
Electrochemiluminescence(ECL) intensity of Ru(bpy)2+3could be enhanced in the presence of clindamycin hydrochloride with the structure of tertiary amine in basic solution.Based on this,a novel ECL method was established for the determination of clindamycin hydrochloride at gold electrode.The electrochemical and ECL characteristics of Ru(bpy)2+3-clindamycin hydrochloride system were investigated by ECL and cyclic voltammetric(CV) method,and the experimental conditions were optimized.Under the optimal conditions,the enhanced ECL intensities had good linear relationship with the concentration of clindamycin hydrochloride in the range of 1.0×105-1.0×10-4 mol/L and 1.0×10-7-8.0×10-6 mol/L,respectively,with a detection limit of 1.0×10-7 mol/L.The RSD for 10 times determination of 2.0×10-5 mol/L clindamycin hydrochloride was 1.74% and the spiked recoveries were 93%-102%.The method showed high selectivity and sensitivity and was applied in the determination of clindamycin hydrochloride in capsule with satisfactory results.
【Fund】: 国家自然科学基金资助项目(20665001);; 广西科学基金资助项目(0640029)
【CateGory Index】: R927.1
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