Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Instrumental Analysis》 2015-08
Add to Favorite Get Latest Update

Investigation on Interaction of Doxorubicin Hydrochloride with Human Telomere DNA by Electrochemical Methods

DU Fang-jing;FENG Rong-rong;HU Xiao-qin;LI Xiao-xia;College of Chemistry and Chemical Engineering of Yan'an University;  
Electrochemical behavior of the anticancer doxorubicin hydrochloride( DOX) and the interaction of DOX with human telomere DNA were investigated by cyclic voltammetry in aqueous medium using p H 6. 0 PBS buffer. The results showed that a pair of reversible oxidation- reduction peaks were observed at- 0. 585 V and- 0. 638 V in p H 6. 0 PBS buffer. There existed excellent linearities between oxidation peak current and concentration of DOX in the ranges of 0. 03- 0. 8 μmol/L and0. 8- 10 μmol/L by linear sweep voltammetric method. Detection limit( S/N = 3) was 0. 01 μmol /L. The relative standard deviations of the oxidation peak current obtained from 11 determinations of the same solutions containing 0. 5 μmol/L DOX were 3. 5%. The oxidation peak current of DOX gradually decreased with the adding of various concentrations of human telomere DNA,due to interaction of DOX with human telomere DNA. The binding ratio was calculated to be 1 ∶ 1 and the binding equilibrium constant was 1. 11 × 103 L/mol.
【Fund】: 陕西自然科学基础研究计划项目(2010JM2020);; 延安大学科研项目(YD2014-04)
【CateGory Index】: O646.54;TQ460.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 Yang Zhijie (Department of Chemistry, Dali Teacher's College, Dali 671000)Liu Shenghui; Ye Jiannong; Fang Yuzhi(department of Chemistry, East China Normal University, Shanghai 200062);Voltammetric Determination of Doxorubicin Hydrochloride With Wax-Impregnated Graphite Electrode[J];Chinese Journal of Analytieal Chemistry;1996-04
2 LIU Jie,LIU Yan-mei and ZHANG Yong(School of Chemistry and Chemical Engineer,Shanxi University,Taiyuan 030006);Study on electrochemical behaviors and analytical application of doxorubicin hydrochloride at a glassy carbon electrode[J];Chinese Journal of Analysis Laboratory;2008-06
3 LI Xiao-xia*,WANG Guo-ling and LUO Xian-wen(College of Chemistry and Chemical Engineering of Yan'an University,Yan'an 716000);Electrochemical behaviors of atenolol and its interactions with bovine serum albumin[J];Chinese Journal of Analysis Laboratory;2013-02
4 JIANG Yuan-Yuan,WANG Kun,XU Chong-Zheng,YANG Xiao-Di,LI Hui-Hui(Jiangsu Key Laboratory of Biofunctional Materials,Jiangsu Key Laboratory of New Power Batteries, School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210097,China);Application of Alizarin/Graphene-Chitosan Modified Electrode on Detection of Human Telomere DNA[J];Chinese Journal of Analytical Chemistry;2013-04
5 GE Chuang,FU Hu,HE Yun and YI Gang*(Key Laboratory of Clinical Laboratory Diagnostics,Ministry of Education,Chongqing Medical University,Chongqing 400016);Flow injection chemiluminescence determination of doxorubicin hydrochloride in plasma[J];Chinese Journal of Analysis Laboratory;2013-06
6 LI Xiao-Xia;DANG Zhuan-Ning;LI Yan-Qing;College of Chemistry and Chemical Engineering of Yan'an University;College of Life Science of Yan'an University;;Study on Interaction of Clenbuterol with Herring Sperm DNA[J];Journal of Analytical Science;2013-06
7 Xu Hui,Mou Baowei,Lv Jubo,Liu Quanwen(School of Chemistry and Materials Science,Ludong University,Yantai 264025);Electrochemical Investigation on the Interaction between Nicotinamide and DNA[J];Chemistry;2009-06
8 CHEN Zhao-hong①,LIU Gui-yang②,WEI Ya-chao①①Hebei North University,Zhangjiakou,075000,China;②Chinese PLA General Hospital,Beijing 100853,China;Determination of Entrapment Efficiency of Doxorubicin Magnetic Thermosensitive Liposomes by Mini-column Centrifugation-Reversed-phase High Performance Liquid Chromatography[J];Pharmaceutical Journal of Chinese People's Liberation Army;2010-06
9 SHANG Yong-hui1,2,LI Hua2,SUN Jia-juan1 (1.School of Chemistry & Chemical Engineering,Xianyang Normal University,Xianyang 712000,China;2.Institute of Analytical Science,Northwest University,Xi'an 710069,China);Linear Sweep Voltammetry Study on Interaction between Metolazone and DNA[J];Journal of Instrumental Analysis;2009-11
10 ZHOU Yan-li,SHEN Fei-fei,YANG Zhi-chong,LI Ling-fang,XU Mao-tian (Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry,Chemistry Department of Shangqiu Normal University,Shangqiu 476000,China);Electrochemical Behavior of Acyclovir on the Boron-doped Diamond Electrode and Its Interaction with DNA[J];Journal of Instrumental Analysis;2011-10
Chinese Journal Full-text Database 10 Hits
1 JIANG Chong-qiu, GAO Ming-xia Department of Chemistry, Shandong Normal University, Jinan 250014, China;Interaction of Epirubicin with Serum Albumin and the Determination of its Content in Serum and Urine Samples[J];Spectroscopy and Spectral Analysis;2003-05
2 ZHANG Huai-bin*,1,WANG Lei1,LIU Xiang-yong1,WEI Guang-cheng1,LI Huai-xiang2 (1.Pharmaceutical College,Binzhou Medical University,Yantai 264003,China; 2.College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China;);The spectral analysis on interaction between breviscapinun and bovine serum albumin in the presence of Zn~(2+)[J];Journal of Molecular Science;2012-05
3 JIAN Xuan,YU Hao*,JIN Jun,WANG Yi,LIU Zhen-ye,QI Guang-cai(College of Chemistry and Chemical Engineering,Yan'an University,Yan'an Shangxi 716000,China);Simultaneous Determination of Dopamine and Uric Acid on Poly-(L-His)/ERGO Modified Glassy Carbon Electrode[J];Journal of Jiangxi Normal University(Natural Science Edition);2013-03
4 YUAN Ze-li;YANG Ming-hui;MO Ming-gui;LE Qing-hua;ZHU Rui-nan;WU Qing;HU Qing-hong;ZHANG Ming-qin;School of Pharmacy,Zunyi Medical College;The Reproductive Center of the First Affiliated Hospital of Zunyi Medical College;;Synthesis of Ti(Ⅳ)-complexes of 1,2,4-triazole schiff base and interaction with DNA by spectrometric techniques[J];Chinese Journal of Analysis Laboratory;2013-11
5 ZHENG Yingying;LIU Zhimin;LI Jie;ZHAN Haijun;College of Chemistry and Chemical Engineering,Henan University of Technology;;Preparation of AChE /IL-GR /CHI /GCE Enzyme Electrode and Its Application for Chlorpyrifos Pesticide[J];Chinese Journal of Sensors and Actuators;2014-04
6 LIU Qiong-yan;HE Xiao-ying;YANG Tao;JIA Jing;College of Chemistry and Chemical Engineering,China West Normal University;;Electrochemical Behavior of Acyclovir at Acetylene Black-Ionic Liquids Composite Modified Electrode[J];Journal of Analytical Science;2014-03
7 DU Fang-jing;BAI Rong-rong;LI Xiao-xia;College of Chemistry and Chemical,Engineering,Yan'an University;;Electrochemical determination of methotrexate and its interaction with lysozyme[J];Chinese Journal of Analysis Laboratory;2014-08
8 ZHANG Man-chen;ZHANG Hong-xing;CHEN Lan;CHEN Ye;School of Chemistry and Chemical Engineering,Xianyang Normal University;;The Preparation and Applications of Doped Chitosan Composites[J];Guangzhou Chemical Industry;2014-23
9 DU Fang-jing;LUO Xian-wen;LI Xiao-xia;College of Chemistry and Chemical,Engineering of Yan'an University;;Electrochemical Behavior of Thiamazole and Its Interaction with DNA[J];Journal of Analytical Science;2015-01
10 LI Can;ZHANG Hong;QI Qian;Department of Pharmacy,Renmin Hospital of Wuhan University;;Preparation of bicyclol solid lipid nanoparticles[J];Journal of Guangdong Pharmaceutical University;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LU Bao-yi,ZHENG You-zhi,LI Hong(School of Chemistry and Environment,South China Normal University,Guangzhou 510006,China);Electrochemical Behavior of 6-substituted Purines and its Interaction with DNA[J];Electrochemistry;2008-01
2 LIN Li-qing,LIN Xin-hua ,CHEN Jing-hua,HUANG Li-ying,LIU Yin-huan,LI Guang-wen ( Department of Pharmaceutical Analysis,Fujian Medical University,Fuzhou 350004,China);Electrochemical Behavior of Kaempferide Interaction with Protein[J];Electrochemistry;2010-02
3 Tan Xuecai; Li Qilong; Shang Jun (Department of Chemistry, Beijing Normal University, Beijing 100875);Single-sweep Oscillopolarography of Adriamycin[J];Chinese Journal of Analytieal Chemistry;1996-07
4 Long Dewu, Liu Chuanyin, Zhao Hongyan, Lu Guanghan * (College of Chemistry, Central China Normal University, Wuhan 430079);Electrochemical Behavior of CuⅡ-Triazolylazo Complex Interaction with Deoxyribonucleic Acid[J];Chinese Journal of Analytieal Chemistry;2002-10
5 Wei Peihai 1, Li Guanbin 2 1(Department of Chemistry, Shandong Institute of Education, Jinan 250013) 2(College of Chemistry and Chemical Engineering, Shandong University, Jinan 250100);Electrochemical Oxidation of Dopamine at a Carbon Paste Electrode Modified with 3-Mercaptopropyltrimethoxysilane Copper Encapsulated in Mesoporous Crystaline Molecular Sieve[J];Chinese Journal of Analytical Chemistry;2005-05
6 Sun Deng-Ming*,Hu Wen-Na,Ma Wei,Su Jin-Yan(Department of Chemistry,Huaibei Coal Normal College,Huaibei 235000);Preparation of Poly(L-Methionine) Modified Electrode and Its Application to the Determination of Uric Acid[J];Chinese Journal of Analytical Chemistry;2007-12
7 YAN Zhi-hong, LI Ju-nan~(*), GAO Peng, MAO Xun(College of Chemistry,Xiangtan University,Xiangtan,Hunan 411105);Determination of Trace Rhein at a Carbon Paste Electrode by Adsorption Voltammetry[J];Journal of Analytical Science;2005-04
8 WANG Xiao-xue1,CHEN Yan-ling*1,MIAO Qi1,JIA Yu-ping2(1.Faculty of Material Science and Chemistry Engineering,China University of Geosciences,Wuhan 430074;2.Xinjiang General Team,Geological Exploration Centreof China Building Material Industry,Wulumuqi 830002);Study on the Electrochemical Behaviors of Uric Acid at OMC-Chitosan Film Modified Electrode[J];Journal of Analytical Science;2009-02
9 WEI Rui-li,LI Xiao-xia,LIU Qi-rui,GAO Luo-jun(College of Chemistry and Chemical Engineering of Yanan University,Shaanxi Key Laboratory of Chemical Reaction Engineering,Yanan 716000);Electrochemical Determination of Amiodarone Hydrochloride and Its Interactions with Bovine Serum Albumin[J];Journal of Analytical Science;2012-03
10 Zhao Huichun; YanNahua and Guo Jinxue (Department of Chemistry,Beijing Normal University, Beijing 100870 ) , FenxiShiyanshi , 1 994 , 1 3 (5) , 36~38This paper describes the determination ofatenolol by flow injection fluorimetry.The methodproposed has th;Rapid Deterinination of Atenolol in Tablets byFlow Injection Fluorimetry[J];Analytical Laboratory;1994-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved