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《Journal of Instrumental Analysis》 2017-08
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Determination of 10 Kinds of Salicylamides in Foods of Animal Origin by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry

ZHOU Si;DENG Long;LIN Sen-yu;HUANG Jia-le;GUO Xin-dong;Guangzhou Inspection and Testing Certification Group Company Limited;Guangdong Food and Drug Vocational College;  
A new method was developed for the determination of 10 kinds of salicylamides,including5-chlorosalicylanilid,4'-bromosalicylanilid,3',4'-dichloro-salicylanilid,4',5-dichloro-salicylanilid,3',4',5-trichloro-salicylanilid,5-bromo-4'-chlorosalicylanilide,3,5-dibromo-salicylanilid,4',5-dibromo-salicylanilid,3,4',5-tribromo-salicylanilid and 3,3',4',5-tetrachloro-salicylanilid in foods of animal origin using solid phase extraction(SPE) combined with ultra-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).Samples were extracted using acetonitrile,and purified with an amino(NH_2) SPE column.The eluent was concentrated by nitrogen gas blowing.10 target compounds were separated on a T3 column(100 mm×2.1 mm,1.8 μm)by gradient elution with methanol -0.1% formic acid as mobile phase,ionized by negative electrospray ionization(ESI-),detected under multiple reaction monitoring(MRM) mode,and quantified by the external standard method.Under the optimized condition,the calibration curves of 10 kinds of salicylamides were linear in a certain concentration range with correlation coefficients(r~2) no less than 0.995 7.The limits of detection(LODs,S/N=3) and limits of quantitation(LOQs,S/N=10) for the target compounds were in the ranges of 0.5-1.0 μg/kg and 1.5-3.0 μg/kg,respectively.The average recoveries at three spiked levels ranged from 81.0% to 106%,with relative standard deviations(RSD,n=6) no more than 7.5%.The method was suitable for the identification and quantification of 10 kinds of salicylamides in foods of animal origin.
【Fund】: 广东省质量技术监督局科技项目(2016PZ09)
【CateGory Index】: O657.63;TS207.5
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