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《Journal of Tianjin University》 2008-06
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Detection of Synthetical Compounds Illegally Mixed into Traditional Chinese Medicine Antidiabetic Preparations by Liquid Chromatography-Mass Spectrometry

LIN Yan-ping1,2,SI Duan-yun2,LIU Chang-xiao2(1.School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;2.Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China)  
Liquid chromatography-mass spectrometry was used to detect synthetical compounds illegally mixed into tradi-tional Chinese medicine antidiabetic preparations.The organic extract of the traditional Chinese medicine antidiabetic cap-sule was analyzed through a C18 column with a mobile phase of methanol-formic acid(80.0∶20.0∶0.1).Two compo-nents illegally added into the traditional Chinese medicine antidiabetic capsule were identified according to the chroma-tographic behavior and mass spectral data by comparison with those of reference substances.As a result,each capsule(400.mg)for oral administration was quantited to contain 2.6 mg phenformin and 2.0 mg glibenclamide.The conclusion is that liquid chromatography-mass spectrometry can be used as a selective and sensitive instrumentality to detect compounds illegally mixed into the traditional Chinese medicine antidiabetic preparations.
【Fund】: 国家自然科学基金资助项目(20675056 30630075)
【CateGory Index】: R286
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