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《Journal of Tongji University(Medical Science)》 2010-05
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Study on the relationship between serum levels of NO,IL-8,IL-10 and IL-18 and the prognosis of patients with acute pancreatitis

SUN Qun,ZHU Jin-shui,ZHANG Qiang (Dept.of Gastroenterology,Sixth People's Hospital,School of Medicine,Shanghai JiaoTong University,Shanghai 200233,China)  
Objective To study the relationship between serum levels of NO,IL-8,IL-10 and IL-18 and the prognosis of patients with acute pancreatitis.Methods Serum levels of NO,IL-8,IL-10 and IL-18 were measured by colorimetric assay and ELISA methods in all patients with mild acute pancreatitis(MAP) or severe acute pancreatitis(SAP) on 1st,4th,7th,and 14th days compared with those from 30 healthy subjects.Results The serum levels of NO,IL-8,IL-10 and IL-18 in MAP as well as in SAP patients were higher than those of healthy subjects,Furthermore,the serum levels of NO,IL-8,IL-18 of patients with SAP were significantly higher than those of patients with MAP,but IL-10 was lower.Conclusion Cytokines IL-8,IL-10,IL-18 and NO were all markedly elevated in patients with acute pancreatitis.IL-8,IL-18 and NO were all positively correlated with the severity of acute pancreatitis.
【CateGory Index】: R576
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