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LIU Shu sen (State Key Laboratory of Biomembrane and Membrane Biotechnology,Zoology Institute,Academia Sinica,Beijing 100080,China) [WT5”FZ]  
In later cases roles of mitiochondrial superoxide anion radicals (O [KG-3][SX(B-3] · 2) in cellular redoxregulation occupied a central position.The mitochondrial respiratory chain not only produced ATP by proton ATPase utilizing proton motive force (ΔμH +) created through the coupling of electron transfer with proton translocation across inner mitochondrial membrane but also generated 95% of O - ·2 of the living body through the reaction of so called“electron leak”pathway.In addition,ΔμH + formed during State 4 respiration by the coupling of electron transfer with proton translocation in respiratory chain was not totally used to synthesize ATP through H + ATPase but could drive protons to go back from the C side to the M side of the inner mitochondrial membrane in coupling with ions exchange or through the passive diffusion of protons.The later case was called as“proton leak”pathway of ΔμH +,which was not associated with ATP synthesis but heat production.Based on recent findings concerning the generating,partitioning,targeting and functioning of superoxide in mitochondria during normal and various pathological conditions,including exercise induced fatigue,a hypothetical model of “reactive oxygen cycle”in respiratory chain to combine both processes of electron leak and proton leak was proposed.In the recent review,some experimental evidences obtained from pervious findings as well as from the others abroad were provided to support this model.A more detailed description of theoretical bases of this model was also presented.
【Fund】: 国家自然科学基金项目! (39370 718;;39870 165)
【CateGory Index】: G804.22
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