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《JOURNAL OF TIANJIN INSTITUTE OF PHYSICAL EDUCATION》 2000-01
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EFFECT OF PLA_2 ON PERMEABILITY TRANSPORTOF MITOCHONDRIAL MEMBRANE

MAO Li juan, XU Hao wen (Dept of Physical Education, East China Normal University, Shanghai 200062,China) [WT5”FZ]  
Free calcium content in rat heart mitochondria changed significantly after exhaustive exercises.Ca 2+ transport confusion was caused by the change of Ca 2+ permeability.of inner mitochondrial membrane The oxidation of SH groups was necessary to increasing mitochondrial permeability transport but not the only factor. Phospholipase A 2(PLA 2)was one of mitochondrial permeability inducers. Mitochondrial Ca 2+ efflux depended on PLA 2 to increase reaction products such as lysophdipids.The increase in PLA 2 activity during exhaustive exercise and the induced change of mitochondrial calcium transport might be one of molecular mechanisms of exercise induced fatigue.
【CateGory Index】: G804.7
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