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Shi Qingde Zhang Yong Chen Jiaqi Liu Shusen  
The present study observes effects of exhaustive exercise on the energy transformation of rat liver mitochondria using treadmill run of SD rats with incremental load as the exercise model. The state 4 respiration rate (R4) , state 3 respiration rate ( R3 ) , respiration control ratio (RCR) and phosphorus/oxygen (ADP/O ) were deter- mined in the presence of malate and glutamate (M+G) or succinate (S) by polarogram method. Results show that t R4 increases by 64. 76 % (P 0. 001 ) , RCR decreases by 15. 05% (P0. 001 ) and ADP/O decreases by 12. 17% (P0. 01 %) respectively in the presence of M + G. R4 increases by 23. 67 % (P 0. 05 ) , RCR decreases by 1 2. 31% (P0. 05) and ADP/O decreases by 11. 76% (P0. 01 ) respectively in the pres- ence of S. Results indicate that the high energy proton leak increases and degree of ox- idative phosphorylation coupling decreases. R3 increases significantly by 41. 14 % (P 0. 001 ) in the presence of M +G and it is speculated that the increase of R3 is due to the compensatory increase of respiration rate in mitochondria resulting from the de- crease of ATP. R3 increases a little without significance in the presence of S. This article suggests that the liver mitochondrial respiration induced by M +G or S is dam- aged after exhaustive exercise and damage of the former is more severe than that of the latter.
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