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《Journal of Tianjin Medical University》 2003-02
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The diagnostic utility of combined determination of CYFRA21-1,NSE,CEA,β_2-MG in patients with lung cancer

ZHANG Wei,CHEN Ying,ZHANG Peng(Cancer Institute & Hospital of Tianjin Medical University,Tianjin 300060,china)  
Objective: To explore the combine determination of CYFRA21-1,NSE,CEA?β2-MG in serum to improve the positive rate in detection of lung cancer,and offer the evidence for clinical diagnose and therapy in early stages.Methods: Serum levels of CYFRA21-1,NSE,CEA?β2-MG were obtained in 155 cases of lung cancer,72cases of benign lung disease and 50 cases of normal by electric chemilluminescent and immunonephelometric method. Results:The combined determination of four tumor markers in the group with lung cancer had a higher positive rate than control.The highest positive rates were 77.7% for CYFRA21-1 in the detection of squamouscell carcinoma,78.4%for NSE in small cell lung cancer,and they were significantly difference from the other patterns of lung cancer respectively.Conclusion: They are reliable tumor markers in diagnosing lung cancer,and helpful to improve the diagnostic positive rate,sensitivity and accuracy.
【CateGory Index】: R734.2
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