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《Journal of Tianjin Medical University》 2009-03
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Study of release on the moleculary imprinted polymer for S-naproxen

HAO Lan-fang,CHEN Yan,HUANG Yan-ping,LIU Zhao-sheng (College of Pharmacy,Tianjin Medical University,Tianjin 300070,China)  
Objective:To describe the development of molecular imprinted technology as a special polymer materials for controlling drugs release.Methods:S-naproxen was used as a template elements,methacrylate as a functional monomer,ethylene glycol methyl ester as the cross-linker,and a mixture of toluene and isooctane as porogen to prepare molecularly imprinted polymers by bulk polymerization.Drug release of the molecularly imprinted polymer was detected using UV spectrophotometry.Results:Release profiles in different PH buffer,content of porogen and the ration of functional monomer and cross-linker showed an obvious control-release effect.Conclusion:MIPs can be used as a controlled-release drug delivery system due to its specific binds to the template.
【Fund】: 国家自然科学基金资助项目(20575045)
【CateGory Index】: TQ460.1
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