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《Journal of Tianjin Medical University》 2009-03
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Study of release on the moleculary imprinted polymer for S-naproxen

HAO Lan-fang,CHEN Yan,HUANG Yan-ping,LIU Zhao-sheng (College of Pharmacy,Tianjin Medical University,Tianjin 300070,China)  
Objective:To describe the development of molecular imprinted technology as a special polymer materials for controlling drugs release.Methods:S-naproxen was used as a template elements,methacrylate as a functional monomer,ethylene glycol methyl ester as the cross-linker,and a mixture of toluene and isooctane as porogen to prepare molecularly imprinted polymers by bulk polymerization.Drug release of the molecularly imprinted polymer was detected using UV spectrophotometry.Results:Release profiles in different PH buffer,content of porogen and the ration of functional monomer and cross-linker showed an obvious control-release effect.Conclusion:MIPs can be used as a controlled-release drug delivery system due to its specific binds to the template.
【Fund】: 国家自然科学基金资助项目(20575045)
【CateGory Index】: TQ460.1
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 ZHU Zheng-bin1,MIAO Jia-bing2,ZHOU Tao2,TANG Ke-wen1(1 Department of Chemistry and Chemical Engineering,Hunan Institute of Science and Technology,Hunan Yueyang 414006;2 College of Chemistry and Chemical Engineering,Central South University,Hunan Changsha 410083,China);Reactive Extraction Kinetics of Phenylsuccinic Acid by Hydroxypropyl-β-cyclodextrin[J];Guangzhou Chemical Industry;2010-05
2 LEI Yong-cheng,SONG Hang~*,FU Chao,JIANG Li-kui (Department of Pharmaceutical & Biological Engineering,Sichuan University,Chengdu 610065,China);Study on resolution of racemic 2-methyl-1-butanol catalyzed by candida cylindrance lipase[J];Chemical Research and Application;2004-02
3 HUANG Ke wen , HU Yong hong , SHEN Shu bao , OUYANG Ping kai College of Pharmacy and Life Science ,Nanjing University of Chemical Technology,Nanjing 210009,China;Recent development on enzyme resolution in pseudo-eutectic systems[J];Journal of Nanjing University;2001-06
4 Sun Deshuai 1,Liu Xin 1,Zhang Xiaodong 1,Hu Yichuan 2 (1. Chemical Engineering Department,Qingdao University,Qingdao 266071; 2. Penglai Qianwei Dyestrff Factory,Penglai;China.);ADVANCE IN ENZYME CATALYZED CHIRAL RESOLUTION OF MEDICINE[J];Journal of Qingdao University Engineering & Technology Edition;2001-03
5 LI Shui-qing,HUANG Yan-sheng(College of Chemical and Environmental Engineering, Yangtze University, Jingzhou Hubei 434025);Summary on the separation methods of chiral compounds[J];Tianjin Chemical Industry;2004-05
6 YANG Liu qing,HE Nan,ZHANG Yu bin ( China Pharmaceutical University,Nanjing 210009, China )[;Biotransformation of chiral drugs[J];Chinese New Drugs Journal;2000-12
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