Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Tianjin Medical University》 2010-02
Add to Favorite Get Latest Update

Effect of hypothermia on the expressions of BDNF in patients with severe traumatic brain injury

YANG Xi-ping1,TU Yue2, DIAO Yun-feng2, DONG Hua-jiang1 (1.Graduate School,Tianjin Medical University,Tianjin 300070, China; 2.Affiliated Hospital of Medical College,Chinese People’s Armed Police Force)  
Objective: To study the effect of hypothermia on the expressions of brain-derived neurotrophic factor (BDNF) and its clinical significance in patients with severe traumatic brain injury (sTBI). Methods: All 50 patients were randomly assigned into two groups,24 patients with hypothermia treatment (hypothermia group), and 26 cases with routine treatment (control group).Hypothermia was induced within 24 hours after brain injury.The expression level of serum BDNF was measured by ELISA method. Meantime,the intracranial pressure (ICP),vital sign, blood gas values,blood electrolytes and arterial oxygen saturation were also measured.According to Glasgow Outcome Scale (GOS),the prognosis was evaluated. Results: Compared with control group,the expression level of BDNF significantly increased (P0.01) , and ICP significantly decreased (P0.01) respectively in hypothermia group. The vital sign,blood gas values, blood electrolytes and arterial oxygen saturation were not significantly changed. No severe complications were found.The mortality was lower and mean GOS of the patients discharge was improved in hypothermia group than that of control group. Conclusion: In the patients with sTBI, hypothermia can protect brain tissue through increasing the expression level of BDNF and decreasing ICP, and it is a safe and effective therapy.
【CateGory Index】: R651.15
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 ZHAO Lin QIN Yi-min WANG Xiao-long Department of Neurosurgery,Tongliao Municipal Hospital in Inner Mongolia Autonomous Region,Tongliao 028000,China;Clinical effect analysis of 100 cases of severe craniocerebral injury treated with mild hypothermia[J];China Modern Medicine;2013-24
Chinese Journal Full-text Database 1 Hits
1 QIU Wu-si *, LIU Wei-guo , SHEN Hong , WANG Wei-min , ZHANG Zhi-liang , ZHANG Ying , JIANG Su-jun and YANG Xiao-feng Department of Neurosurgery, Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China (Qiu WS, Liu WG, Shen H and Yang XF)Department of Neurosurgery, Second Affiliated Hospital, Hangzhou Normal College, Hangzhou 310012, China (Qiu WS, Wang WM, Zhang ZL, Zhang Y and Jiang SJ);Therapeutic effect of mild hypothermia on severe traumatic head injury[J];中华创伤杂志(英文版);2005-01
Chinese Journal Full-text Database 8 Hits
1 XUE Kai1,ZHANG Sai2 (1. Graduate School ,Tianjin Medical University,Tianjin 300070,China; 2.Affiliated Hospital of Medical College of Chinese People’s Armed Police Force);The influence of traumatic brain injury and mild hypothermia therapy on patients' cerebral blood flow[J];Journal of Tianjin Medical University;2007-03
2 CHEN Ai,ZHOU Hui,TONG Yu,MAO Meng (Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China);Brain-Derived Neurotrophic Factor Through Autophagy to Protect Oxygen Deprived Cerebral Cortical Neurons in Embryonic Rats[J];Journal of Applied Clinical Pediatrics;2012-17
3 SONG Xiang-qi;CHEN Tong;FU Ai-jun;ZHU Jun;LI Jian-min;XIAO Zeng-bing;WANG Rui-gang;Department of Neurosurgery, the Affiliated Hospital of Hebei United University;;Mild hypothermia therapy on the efficacy and safety in patients with severe traumatic brain injury:a systematic review[J];The Journal of Practical Medicine;2014-07
4 Liu Wei1, An Yi-hua2, Liu En-zhong3, Yu Chun-jiang3 1Department of Neurosurgery, Shanxi Bo'ai Hospital, Taiyuan 030001, Shanxi Province, China; 2Beijing Neurosurgical Institute, Beijing 100050; 3Department of Neurosurgery, First Clinical Medical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China;Effect of mild hypothermia combined with hibernation on the homeostasis of patients with severe head injury[J];Chinese Journal of Clinical Rehabilitation;2005-33
5 Chen Bao-guo,Huang Wei-qing Department of Plastic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100032,China;Brain-derived neurotrophic factor and repair and regeneration of injured nerves[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-15
6 CHEN Han-xiao,JIN Mao-qiang,WU Xiao (Department of Pathology,Xinjiang Medical University,Urumuqi 830011,China);Expression of COX-2,BDNF,PDGF-B after closed traumatic brain injury in rats[J];Journal of Xinjiang Medical University;2010-12
7 PAN Ya ,DAI Tao-Li ,YANG Qiong,et al.Department of Physiology,Guiyang Medical College,Guiyang 550004,Guizhou,China;Effect of Aniracetam on the expression of brain-derived neurotrophic factor of hippocampal in vascular dementia rats[J];Chinese Journal of Gerontology;2009-03
8 LIU Guodong, LAN Qing Department of Neurosurgery, Second Affiliated Hospital to Soochow University, Suzhou 215000, China;A Meta analysis of hypothermia for severe traumatic brain injury[J];Chinese Journal of Minimally Invasive Neurosurgery;2009-05
Chinese Journal Full-text Database 7 Hits
1 SHEN Ya-feng1,TU Yue,CHENG Shi-xiang,SUN Hong-tao,ZHANG Sai(1 Graduate School of Tianjin Medical University,Tianjin 300070,P.R.China);Influence of moderate hypothermia on cerebrospinal fluid amyloid β peptide level and prognosis in severe traumatic brain injury patients[J];Shandong Medical Journal;2011-02
2 CHEN Hehong,ZHI Dashi,ZHANG Sai Mild Hypothermic Treatment Center,Tianjin Huanhu Hospital,Tianjin300060,China;Study on Continuous Monitoring of Brain Oxygen Metabolism during Mild Hypothermia in Patients with Severe Head Injury[J];Tianjing Medical Journal;2004-01
3 ZHENG Qingtang,CHEN Zhuo,XIE Congmin(Department of Neurosurgery,the Affiliated Shilong Bo'ai Hospital of Guangdong Medical College,Dongguan 523325,China);Application research of ultra-early hypothermia on the treatment of severe traumatic brain injury[J];China Medical Herald;2010-19
4 FAN Ling,HUANG Xing-hua;Talk about the selection of caesarean section types again[J];Chinese Journal of Practical Gynecology and Obstetrics;2008-10
5 HUANG Yangxiao (Department of Neurosurgery, Dongkeng Hospital, Dongguan City, Guangdong province, Dongguan 523451, China);Application of mild hypothermia hibernation in the therapy of severe brain trauma[J];China Modern Medicine;2010-14
6 XIA Yongqin *, XU Ruxiang, WANG Xiangyu. * Department of Neurosurgery, 16th Hospital of PLA, Aletai 836500, China;Effect of mild hypothermia on cerebral hemodynamics after severe head injury[J];CHINESE JOURNAL OF TRAUMATOLOGY;2000-10
7 SHI Di-jian,et al(Department of Neurosurgery,the Third People's Hospital of Chongqing);Effect of moderate hypothermia on inflammatory cytokines levels in cerebrospinal fluid after severe traumatic brain injury[J];Journal of Chongqing Medical University;2010-05
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 ZHANG Jun;XIE Ren-long;Department of Neurosurgery,the First People’s Hospital of Xiaoshan District of Hangzhou City;;Clinical study of minimally invasive surgery and Gaja hypothermia in the treatment of hypertensive cerebral hemorrhage[J];Chinese Journal of General Practice;2014-02
2 ;The treatment of severe head trauma Outside a branch Yuan Li barkam sichuan ruoergai county people's hospital[J];Contemporary Medicine Forum;2014-05
3 HUA Zheng-yu,ZHANG Chun-lei.Department of Pathology of First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;Mechanism and Clinical Application of Mild Hypothermia[J];Medicine & Philosophy(Clinical Decision Making Forum Edition);2011-12
4 Pengbai Memorial Hospital of Haifeng County,Haifeng 516400,China;Application and nursing of mild hypothermia on patients with severe brain injury[J];Medical Innovation of China;2012-02
5 CAI Lingfen ZHONG Lihua JIN Lingjiang LIN Da YIN Kang HE Wengen YANG Jianping XU Ru LIN Zheng Deparment of Cerebral Surgery,the First People′ s Hospital of Wenling City,Zhejiang Province,Wenling 317500,China;Application study of early ventilation combined mild hypothermia hibernation on patients with severe traumatic brain injury[J];China Medical Herald;2013-15
6 ZHAO Lin QIN Yi-min WANG Xiao-long Department of Neurosurgery,Tongliao Municipal Hospital in Inner Mongolia Autonomous Region,Tongliao 028000,China;Clinical effect analysis of 100 cases of severe craniocerebral injury treated with mild hypothermia[J];China Modern Medicine;2013-24
7 WANG Fa-wen;Jingdezhen Hospital of Traditional Chinese Medicine;;Contrast and Analysis of the Application Effects of Mild Hypothcrmia and Normal Temperature Treatment on Serious Cerebral Hemorrhage[J];Medical Innovation of China;2013-35
8 ZHOU Jun;YANG Li;YU Bao-zhan;Department of the Second Surgery, Affiliated Staff Hospital of Petroleum Prospecting of Hebei University;;Clinical study on mild hypothermia on severe traumatic brain injury patients with acute traumatic coagulopathy[J];China Medical Equipment;2014-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved