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《Journal of Tianjin Medical University》 2010-02
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Effect of hypothermia on the expressions of BDNF in patients with severe traumatic brain injury

YANG Xi-ping1,TU Yue2, DIAO Yun-feng2, DONG Hua-jiang1 (1.Graduate School,Tianjin Medical University,Tianjin 300070, China; 2.Affiliated Hospital of Medical College,Chinese People’s Armed Police Force)  
Objective: To study the effect of hypothermia on the expressions of brain-derived neurotrophic factor (BDNF) and its clinical significance in patients with severe traumatic brain injury (sTBI). Methods: All 50 patients were randomly assigned into two groups,24 patients with hypothermia treatment (hypothermia group), and 26 cases with routine treatment (control group).Hypothermia was induced within 24 hours after brain injury.The expression level of serum BDNF was measured by ELISA method. Meantime,the intracranial pressure (ICP),vital sign, blood gas values,blood electrolytes and arterial oxygen saturation were also measured.According to Glasgow Outcome Scale (GOS),the prognosis was evaluated. Results: Compared with control group,the expression level of BDNF significantly increased (P0.01) , and ICP significantly decreased (P0.01) respectively in hypothermia group. The vital sign,blood gas values, blood electrolytes and arterial oxygen saturation were not significantly changed. No severe complications were found.The mortality was lower and mean GOS of the patients discharge was improved in hypothermia group than that of control group. Conclusion: In the patients with sTBI, hypothermia can protect brain tissue through increasing the expression level of BDNF and decreasing ICP, and it is a safe and effective therapy.
【CateGory Index】: R651.15
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