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《Journal of Huazhong University of Science and Technology(Medical Sciences)》 2006-01
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Influence of SB203580 on Cell Apoptosis and P38MAPK in Renal Ischemia/Reperfusion Injury

LI Rongshan 1, 2 , DING Tao 2 , LIU Xiaocheng 1 , LI Caixia 2 1 Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Department of Nephrology, Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China  
The effects of SB203580 (SB) with different concentrations at different time points on renal function, apoptosis, P38MAPK activity and the expression, as well as the P38MAPK substrates in renal ischemia/reperfusion injury were investigated. Forty-nine rats were divided into 7 groups at random (n=7 in each group) according to the durations of ischemia/reperfusion injury and the time of medication. Based on the orthogonal Latin side, the rats were injected, by caudal vein, with the same volume but different dosages of SB. BUN and Scr were determined. The apoptosis was detected with TUNEL kit. The protein was assayed qualitatively and semi-quantitatively by Western blot. The results showed that SB could significantly reduce the increased Scr and BUN, the apoptosis of renal tubular epithelia and the activation of P38MAPK all caused by renal ischemia/reperfusion injury in a dose-dependent manner (P0.05). And the effect was most predominant when SB was given 3 h before renal ischemia. This suggested that SB could significantly alleviate renal ischemia/reperfusion injury. Administration of SB 3 h before ischemia at the concentration of 5 μmol/L could obtain an optimal effect.
【Fund】: ThisprojectwassupportedbyagrantfromNaturalSci-encesFoundationofShanxiProvince(No.20001072).
【CateGory Index】: R692
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【References】
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【Co-references】
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1 LU Meisong 1, XIAO Lan 2, LI Zhimin 3, HU Jianli 4 1Department of Gynecology and Obstetrics, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China 2 Department of Gynecology and Obstetrics, the Third Affiliated Hospital of Sun Yan-sen University, Guangzhou 510630, China 3Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 4The Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430023, China;The Relationship between p38MAPK and Apoptosis during Paclitaxel Resistance of Ovarian Cancer Cells[J];华中科技大学学报(医学英德文版);2007-06
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5 ZHANG Shui-wen1, SUN Feng-ling1, ZANG Tong1, SONG Bo2 (1.Department of Urinary, the General Hospital of Beijing Military Command, Beijing 100700, P.R.China; 2.Urinary Surgery Center of PLA, Western South Hospital, Chongqing 400038, P.R.China);Cerebral evoked potentials effected by activation of astrocyte for pain from chronic prostatitis[J];China Journal of Modern Medicine;2008-10
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7 Ying JIN~(2,4) Ying FAN~2 En-zhi YAN~2 ghuo LIU~2 Zhi-hong ZONG~3 Zhi-min QI~2 ~2Department of Pharmacology,Jinzhou Medical College,Jinzhou 121001,China;~3Department of Biochemistry,China Medical University,Shenyang 110001,China;Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus[J];中国药理学报(英文版);2006-10
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