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《Acta Universitatis Medictnae Tangji》 1994-03
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The Effects of Andrographis Paniculata Nees on Myocardial Intracellular K~+,Na~+,Ca~(2+),Mg~(2+)in the Course of Ischemic Reperfusion

Guo Zhiling;Zhao Huayue;Zheng Xinhua;et alDepartment of Cardiology,Tongji Hospital,Tongji Medical University,Wuhan 430030  
The intracellular Ca~(2+), Na~+ were increased,K~+ and Mg~(2+) decreased markedly in ischemic area of dogs undergoing left anterior descending coronary artery(LAD)ligation for 90 min and subsequent reperfusion for 60 min,as compared with sustained ischemia for 150 min.The occurrence rate of ventricular arrhythmia was high.Whereas in group pretreated with APN,in comparison with control group,the Ca~(2+)in relevant area was decreased(P<0.05),Na~+ markedly decreased,K~+ significantly increased(P<0.01),Mg~(2+) increased(P<0.05).The rate and grade of ventricular arrhythmia were rarer and milder. These data suggest that APN may prevent the intramyocardial increase of Na~+ Ca~(2+) and the 1oss of K~+,Mg~(2+)and it may explain the basic mechanism in decreasing the reperfusion arrhythmia.
【CateGory Index】: R285
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