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Antioxidation of Pueraria Lobata Isoflavones

Zhang Guangcheng; Fang Siming (Department of Biology, School of Basic Medical Sciences, Tongji Medical University, Wuhan 430030)  
By studying the effect of pueraia lobata isoflavones (PLIs) on lipid peroxide (LPO) and superoxide dismutase (SOD) in animal tissue, this paper suggests that PLIs is an effective antioxidant. The results in vitro showed that PLIs could inhibit significantly the content of LPO. The highest inhibition rates were found to be 79.7%, 84.7% and 86.6% in liver, kidney of mice and brain of rabbit respectively. In the case of cold induced brain injury with chalcone, the content of LPO and activity of SOD in animal blood and brain were changed. When anima1s were injected with PLIs, the result indicated that the PLIs could reduce significant1y the content of LPO and enhance the activity of SOD in animal blood and brain, being in a dose-dependent relationship.
【Fund】: 国家自然科学基金!No.39070962
【CateGory Index】: R285
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