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Effects of Andrographis Paniculate Component API_(0134) on Nitric Oxide and Endotheliolysin in Experimental Rabbits with Mesangial Proliferative Glomerulonephritis

Wu Hengsheng, Wang Hongwei, Liu Tonglin et al Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030  
To study the mechanism of andrographis paniculate API 0134 to prevent and treat mesengial proliferating glomerulonephritis (MSPGN) in rabbits, the model of rabbit MSPGN was developed by single injection of forage containing high cholesterol and bovin serum album. Affer 4 to 8 weeks, the serum nitric oxide (NO), plasma endotheliolysin (ET), cGMP and lipid peroxide were measured and morphologic change of renal tissue examined. The results showed that as compared with the model group preventive use of andrographis paniculate component API 0134 for 4 to 8 weeks could increase serum content of NO, CGMP and SOD activity ( P 0.01), and decrease the contents of ET and LPO ( P 0.01). The renal pathological damage was slight, while the lesions in the model group was more severe. It was considered that API 0134 has the effect of antioxidation, can protect the mesengial cells, maintain NO/ET balance and prevent the renal tissure from pathologic changes.
【Fund】: 湖北省科委资助!项目 (No. 982 0 12 0 4)
【CateGory Index】: R284
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