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《Acta Universitatis Medictnae Tangji》 2002-01
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Study on the Mechanisms of A-L Tonic Capsule Inhibiting Rat Hepatocellular Carcinoma

Guan Yang, Zhou Zebin, Ruan Youbing et al Department of Ultrastructural Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030  
By using immunological and pathological methods, the influence of A-L tonic capsule on serum concentrations of IL-2 and TNF, NK cell activity as well as liver morphological change was observed in 4 different experimental groups of rats during hepatocarcinogenesis induced by diethylnitrosamine (DENA). The results showed that NK cell activity of rats in the group A, in which the rats were preventively administered by A-L tonic capsule for 8 weeks followed by DENA, was markedly higher than in the group D, in which the rats were only given DENA, P0.01. Serum concentrations of IL-2 and TNF in the group A had a tendency to increase as compared with that in the group D. Liver tissue toxic injury induced by carcinogen in the group A was also milder than that in other experimental groups. It was indicated that A-L tonic capsule could enhance anti-cancer ability of the rats, reduce liver tissue toxic injury induced by carcinogen and postpone hepatocarcinogenesis.
【CateGory Index】: R273
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