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《Acta Universitatis Medictnae Tangji》 2004-05
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Protective Effect of Nitric Oxide on Gastric Mucosa

Liu Jinsong, Hou Xiaohua△ Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022  
Objective To observe the protective effect of nitric oxide on gastric mucosa and gastric mucosa protective factors, therefore, to investigate its protective mechanism. Methods Eighty male Wistar rats were randomly divided into 4 groups (n=20 in each) for detection of 4 parameters. Each group was assigned to the following subgroups: control subgroup, L-arg subgroup (L-arginine 200 mg/kg, i.p), L-NAME subgroup (L-NAME, 3 mg/kg, i.p) and L-NAME+L-arg subgroup. 1.5 ml 100 % alcohol was infused orally in all 4 groups. The area of gastric ulcer and depth was measured 15 min after the infusion. Levels of nitric oxide in gastric mucosa, blood flow of gastric mucosa and level of HCO_3-in gastric mucus were measured by Grees-reaction method, natural red secretion method and gastric mucosa chember method respectively. Results As compare with the control subgroups, the area and depth of gastric ulcer induced by alcohol were significantly decreased, and the level of nitric oxide, gastric mucosa blood flow and the level of HCO_3- were increased in L-arg subgroups. The protective effect was completely abolished by L-NAME. Whereas, L-NAME itself could increase the area and depth of gastric ulcer induced by alcohol, decrease the level of nitric oxide, gastric mucosa blood flow and level of HCO_ 3-. Conclusion Nitric oxide can prevent the gastric mucosa from the invasion factor and this effect is associated with the increased blood flow of gastric mucosa and secretion of HCO_3-.
【CateGory Index】: R573
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