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《Acta Medicinae Universitatis Scientiae et Technologiae Huazhong》 2007-05
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Effect of Down-regulation of Serum High Mobility Group box Protein 1 Expression on Systemic Capillary Leakage of Rats with Acute Hemorrhagic Necrotizing Pancreatitis

Yang Zhiyong,Tao Jing,Zhou Feng et al Pancreatic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022  
Objective To study the effect of the down-regulation of serum high mobility group box protein 1(HMGB1) expression on systemic capillary leakage(SCL) of rats with acute hemorrhagic necrotizing pancreatitis(AHNP).Methods Rat AHNP model was induced by retrograde injection of artificial bile into the pancreatic duct.Animals were randomly divided into 4 groups:normal control group(n=8),Sham group(n=8),AHNP group(n=16) and ethyl pyruvate(EP)-treated group(n=16).The rats in EP-treated group were administrated with EP(30 mg/kg,12 and 18 h post-AHNP).HMGB1 serum levels were detected by Western blotting.Evan's blue dye(EBD) was injected into caudal vein to evaluate protein leakage.The index related to water and protein leakage was detected.Results 24 h after operation,serum HMGB1 levels,ascites volume,lung coefficient,lung wet to dry ratio,EBD content in pancreas,jejunum,ileum and auricle tissue in EP group were significantly lower than in AHNP group.Conclusion Down-regulation of serum HMGB1 levels could effectively alleviate SCL in AHNP rats.
【Fund】: 国家自然科学基金资助项目(No30600593)
【CateGory Index】: R576
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