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《Acta Medicinae Universitatis Scientiae et Technologiae Huazhong》 2008-04
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Expression of LMP-1 in Nasopharyngeal Cancer Tissue and Its Relation with Peripheral Blood EBV-IgA/VCA

Chu Hanqi, Xiong Hao, Jamal Alhosam et al Department of Otolaryngology, Institute of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030  
Objective To investigate EB virus infection and LMP-1 expression in patients with nasopharyngeal carcinoma (NPC). Methods Biopsied materials of 62 cases of NPC and 33 cases of nasopharyngitis were collected. In all cases, LMP-1 was detected by immunohistochemistry and EBV by immunoenzyme method respectively. Results The positive rate of serum EBV-IgA/VCA was 90.32% (56/62) in NPC patients, and 3.03% (1/33) in nasopharyngitis patients (P0.05). The positive expression rate of LMP-1 was 59.68% (37/62) in NPC, and 6.06% (2/33) in nasopharyngitis (P0.05). The co-expression rate of EBV-IgA/VCA and LMP-1 was 62.5% (35/56) in NPC patients. Conclusion The high co-expression levels of EBV-IgA/VCA and LMP-1 may contribute to the development of NPC.
【Fund】: 国家自然科学基金资助项目(No30672307)
【CateGory Index】: R739.63
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