Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Medicinae Universitatis Scientiae et Technologiae Huazhong》 2008-06
Add to Favorite Get Latest Update

Effect of Gap Junction on Delayed Neuronal Death in Rat Hippocampus after Middle Cerebral Artery Occlusion and the Neurological Scores

Yi Chenju,Xu Shabei,Tang Yingxin et al Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030  
Objective To explore the effect of blocking gap junction communication after focal cerebral ischemia on delayed neuronal death in ipsilateral hippocampus and the neurological scores. Methods A rat model of middle cerebral artery occlusion (MCAO) was made by the intraluminal occlusion technique. Carbenoxolone,a gap junction blocker,was used to block gap junction communication,and the effect of blocking gap junction communication after focal cerebral ischemia on delayed neuronal death in the ipsilateral hippocampus was observed by Nissl's staining and the neurological scores were evaluated in all rats in 24 h and 3 days after operation. Results With no inhibition of gap junction communication,delayed neuronal death was detected in 45% of the animals in hippocampal CA1 region 3 days after middle cerebral artery occlusion. With the inhibition of gap junction communication,delayed neuronal death appeared in only 30% of the animals,which was significantly lower than that of control group (P0.01). Meanwhile,compared with those in control group,the neurological scores of the animals in experimental group were significantly reduced (P0.01). Conclusion Blocking gap junction communication can reduce the incidence of delayed neuronal death in hippocampus after MCAO,and can prevent neurological deficiency after MCAO.
【Fund】: 国家自然科学基金资助项目(No.30600187);; 国家杰出青年科学基金资助项目(No.30725091);; 湖北省自然科学基金资助项目(No.2007ABA174)
【CateGory Index】: R743.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved