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《ACTA UNIVERSITATIS MEDICTNAE TANGJI》 1999-02
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Effects of API 0134 on the Thrombin induced Platelet Cyclic Nucleotide and Cytoplasmic Free Ca 2+

Li Shusheng 1, Zhao Huayue 2, Guo Zhiling 2 1 Department of Emergency Medicine, 2 Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030  
In order to observe the inhibitory effect of Andrographis Paniculata Isolate 0134(API 0134 ,API) on the anti thrombin induced platelet activation, 24 domestic rabbits were randomly divided into API pretreated group ( n= 9), ticlopidine (T) pretreated group ( n= 8), and control (C) group ( n= 7). The rabbits received the treatment for 1 week. After induction with thrombin following parameters were measured: cAMP, cGMP and concentration of cytoplasmic free Ca 2+ . Ultrastructural changes of platelets were also examined. cAMP level was markedly higher in API and T groups than in C group ( P 0.05), while the concentration of free Ca 2+ in both API and T groups was markedly lower than in C group ( P 0.01). The ultrastructural changes of platelets showed the degranulation in API and T groups was much milder than in C group. API may inhibit thrombin induced activation of platelets.
【Key Words】： API 0134 cyclic nucleotide calcium ion thrombin platelet activating ticlopidine
【Fund】： 卫生部默沙东科研基金
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