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《Chinese Journal of Traditional Medical Science and Technology》 2001-01
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EFFECT OF JIANPIHUOXUE FORMULA ON RATS' HEPTATIC STEATOSIS INDUCED BY CCl_4 WITH HIGH FAT AND LOW PROTEIN DIET

He Dong-yi,et al (Institute of Liver Disease,Shanghai University of TCM,Shanghai 200032)  
Objective:To observe the effects of Jianpihuoxue Formula (JPHXF) on fat ty liver and to investigate its mechanism.Method:Fatty liver model was induced b y tetrachloride carbon (CCl 4) with high fat and low protein diet in rats. Afte r treated with JPHXF or Dongbaogantai (DBGT) as control.Sample of liver and blood in these rats were examined by means of histopathological,histochemica l and electronic-microscopic observation,as well as hepatic tissue triglyceride (TG) and total cholesterol (TC) assay and some serum test. Result:The results showed that JPHXE could attenuate hepatic injury and hept atic steatosis significant ly,and could also decease the hepatic TG,elevate the superoxide dismutase (SOD) co ntent.Conclusion:These data imply that JPHXF has a good action on heptatic s teatosis,the mechanism of its action is mainly associated with adjusting metabol ism of liver fat and tricarboxylic acid cycle,as well as accelerating fatty acid β-oxidation in metochondria of hepatocyte and resisting lipoperoxidation.
【CateGory Index】: R285.5
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