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《Tianjing Medical Journal》 1994-07
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Assay and Clinical Significance on Lymphocyte Subpopulation and Autoantibodies in Patients with Autoimmune Thyroid Diseases

Zhong Shuyou, et al Immunology Laboratory, Tianjin Medical College Hospital  
Lymphocyte subpopulations and autoantibodies were investigated in 150 patients with autoimmune thyroid diseases and 25 patients with subacute thyroiditis. In the untreated group of Graves' disease (GD) and Hashimoto thyroiditis (HT) CD3+ and CD8+ were markedly declined while the ratio of CD4+CD8+ and CD20+ were significantly elevated (P0.01. In the untreated group of GD, the positive rate for TRAb, TMA and TGA were 88.9%, 66.1% and 57-8% respectively, while they were 20.0%, 76.7% and 70.0% in the untreated group of HT. There was no significant change found in the subacute thyroiditis. In the remitted group of GD, these indices were turned to the normal limits. It was noted in the untreated GD group that there wasa stronger negative correlation between TRAb and CD8+ than the positive correlation between TRAb and CD20+. The data suggest that CD8+, CD20+ and TRAb might be the reliable indices for the judgement of the treatment and prognosis of Graves' disease.
【CateGory Index】: R581
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