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《Tianjing Medical Journal》 2005-12
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Study on the Protective Effects of Lytic Cocktail and JIAWEIDANSHENYIN on Stress Ulcer in Rabbits

LI Zhijun, SUN Yuanying, LIU Nawen, LIU Hongshuan, WANG JindaThe Emergency Medicine Research Institute of Tianjin First Central Hospitial, Tianjin 300192, China  
Objective: To study the protective effects of the integrated traditional Chinese and western medicine on stress organ damage in rabbits. Methods: Forty rabbits were randomly divided into four groups including control group (group I), the model control group (group Ⅱ), western medicine group (group Ⅲ), and the integrated traditional Chinese and western medicine group (group Ⅳ). The stress organ damage models were made by soaking in water, pour stomach with traditional Chinese medicine JIAWEIDANSHENYIN twice a day for five days in group IV before model building, and lytic cocktail were injected in group Ⅲ and group Ⅳ after model building. Cortisol (COR), thromboxane A2 (TxA2), endothelium (ET), nitrogen monoxide (NOS) and the pathologic change of the gastric mucosa were observed at different time in each group. Results: COR increased significantly in group Ⅱ compared with that in group I (P 0.01), COR decreased in group Ⅲ and group Ⅳ, there was no significant difference between the two groups (P 0.05). The content of ET, NOS and TxA2 decreased significantly in group Ⅳ compared with that in group Ⅲ (P 0.05). The pathologic change of the gastric mucosa improved in group Ⅳ compared with that in group Ⅲ. Conclusion: The lytic cocktail and JIAWEIDANSHENYIN have good protective effects on stress ulcer.
【CateGory Index】: R285
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