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《Tianjin Medical Journal》 2012-05
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Meta-Analysis of Randomized Controlled Trials of Linezolid Versus Vancomycin for Treatment of MRSA Infections in Children

YANG Nanzhu, WU Yuqiu, YUN Xianghua Tianjin First Hospital, Tianjin 300232, China  
Objective:To investigate a Meta-analysis of randomized controlled trials on the efficacy and safety of line zolid versus vancomycin on treatment of methicillin resistant staphylococcus aureus (MRSA) infections in children. Methods: Data were collected from the Medline database, EMBASE,Ovid and Chinese CNKI database. The literatures met the inclu sion criteria were screened and performed by Meta-analysis. The cure rate and incidence of adverse reactions in MRSA infec tions were compared in children treated with linezolid and vancomycin. Results: Three randomized controlled studies were analyzed in this study including 588 children with MRSA infections. Clinical cure rate of linezolid was 89.72%, which was better than that of vancomycin (85.71%), but no significant difference between the two groups (89.72% vs 85.71%, RR = 1.05, 95% CI (0.98, 1.12), Z = 1.49,P = 0.14]. Drug-related adverse event in linezolid-treated patients was 17.5%(70/399), which was significantly lower than that of vancomycin-treated patients 35.9%(68/189) [RR = 0.49,95%(0.37,0.65), Z = 4.93,P 0.01]. Conclusion:Linezolid was equivalent to vancomycin for the treatment of MRSA infections in children, and linezolid was more safe for the treatment than that of vancomycin.
【CateGory Index】: R446.5
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