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《Tianjin Medical Journal》 2013-07
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Effects of Sevoflurane Postconditioning on Lung Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass

HE Keqiang, WANG Ruiting , XIE Zhiqiong, PAN Jianhui, CHAI Xiaoping Department of Anesthesiology, the Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China  
Objective To investigate the effects of sevoflurane postconditioning on lung function in patients undergo ing heart valve prosthesis implantation with cardiopulmonary bypass (CPB). Methods Thirty patients, scheduled for heart valve prosthesis implantation, were randomly divided into control group (C, n =15) and sevoflurane postconditioning group (S, n =15). Anesthesia was maintained by intermittent intravenous injection of midazolam, fentanyl and pipecuronium. In group S, 2% sevoflurane was inhaled continuously for 15 min , 2 min before aortic unclamping. Blood samples were taken at 30 min before CPB (T2), 30 min after CPB (T3), 6 h (T4), 12 h (T5) and 24 h (T6) after operation. The values of p( O 2 ) , SaO 2 , airway peak pressure (P peak ) and airway plateau (P plat ) pressure during the time of mechanical ventilation were recorded. Oxygen index (OI), alveolar arterial oxygen tension difference (AaDO 2 ), dynamic pulmonary compliance (C dyn ) and static pulmonary compli ance (C stat ) were calculated. Results Compared with group C, the values of SaO 2 and C dyn were significantly higher in group S after 30 min of CPB. The values of OI, p( O 2 ) , C dyn and C stat were significantly higher in group S than those of group C after 6 h of operation. The value of AaDO 2 was significantly lower 12 h and 24 h after operation than that of group C ( P 0.05). Conclusion CPB led to the lung injury. The sevoflurane postconditioning has a protective effect on lung function in pa tients undergoing cardiac valve replacement with CPB.
【Fund】: 安徽省卫生厅医学科研课题资助项目(项目编号:09A065)
【CateGory Index】: R614
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