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Effect of Buzhong Yiqi decoction on the kidney function,morphology and VEGF expression in rats with hypothyroid kidney damages

ZHANG Jing1,GAO Tian-shu2,FAN Qiu-ling3,SHAN Zhong-yan4(1.Liaoning Univer of TCM,Shenyang 110032,China;2.Department of Endocrinology,The First Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,China;3.Kidney Medical Department,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;4.Department of Endocrinology,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)  
[Objective] To study effect of Buzhong Yiqi decoction on the kidney function,morphology and VEGF expression in rats with hypothyroid kidney damages.[Methods] The rats were divided randomly into experiment group and normal group.56 days later we detected the level of serum TT3,TT4,TSH,SCr and BUN,observed the morphologic change of the kidney and the VEGF expression.[Results] 1)Compared with normal control group,the level of serum BUN(P0.05) and SCr(P0.05) in L-T4 group and model increased.2)About VEGF optical density,compared with normal control group,each group had no obvious difference.Compared with model group,Buzhong Yiqi decoction group increased obviously(P0.01).3)About PAS staining,on the 21 days of treatment,model group displayed slightly hyperplasia;after 56 days treatment,model group displayed medium hyperplasia,the hyperplasia in Buzhong Yiqi decoction group was most slight among two treatment groups.[Conclusion] The conceivable mechanism of hypothyroid kidney damages is the loss of the glomerular capillaries.Buzhong Yiqi decoction can increase the endocrine function of VEGF and the rising VEGF in kidney plays a protective role for hypothyroidisn.
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