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《Chinese Scientific Journal of Hearing and Speech Rehabilitation》 2016-05
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The Clinical Effects of Batroxobin Combined with Vinpocetine in the Treatment of Senile Sudden Deafness

LIU Gen-jiu;LI Sui-qin;  
Objective To investigate the clinical effects of batroxobin combined with vinpocetine in the treatment of senile sudden deafness.Methods 176 cases of senile patients with sudden deafness were selected and treated at our hospital from January 2013 to December 2015.They were divided into two groups randomly.The vinpocetine group was given vinpocetine,the combination group was given batroxobin combined with vinpocetine.The therapeutic effects,blood rheology,coagulation functions and pure tone thresholds of the two groups were observed.Results The effective rate of combination group was 89.78%(79/88),significantly higher than that of the vinpocetine group which was 70.54%(62/88)(P0.05).After treatment,low shear whole blood viscosity,high shear whole blood viscosity.plasma viscosity and hematocrit of the two groups were significantly reduced(P0.05) and the combination group decreased more obviously(.P0.05).The activated partial thromboplastin time,and thrombin time,prothrombin time were significantly increased(P0.05),while plasma fibrinogen decreased significantly(P0.05).The two groups had no significant differences(P0.05).The pure tone thresholds of the two groups were significantly improved(P0.05),and the combination group was more obvious(P0.05).Conclusion Batroxobin combined with vinpocetine had noticeable effects on the treatment of senile sudden deafness,and could effectively improve the patient's blood hypercoagulable state and hemorheology state.
【CateGory Index】: R764.437
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【References】
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【Citations】
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1 KU Wei;LIU Yehai;WU Jing;WANG Qiang;TONG Busheng;DUAN Maoli;Otolaryngology,First Affiliated Hospital of Anhui Medical University;Karolinska University Hospital Department of Clinical Science,Intervention and Technology,Department of Otolaryngology Head and Neck,Department of Neurotology and audiology;;Meta-analysis of the clinical efficacy of treatment of sudden deafness using hyperbaric oxygen combined with drug in China[J];中华耳科学杂志;2014-01
【Co-citations】
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1 LI En-jian;The Third People’s Hospital of Liaoyang;;Observation on the Influence of Hyperbaric Oxygen Therapy on Patients with Sudden Deafness Symptoms,Signs and Blood Viscosity Index[J];中国医学创新;2017-21
2 ZHANG Shu'e;;Therapeutic effect of combined hyperbaric oxygen and intratympanic injection of methylprednisolone on sudden sensorineural hearing loss[J];职业卫生与应急救援;2017-03
3 Yang Li;Gan Qiang;Fang Hongyan;Yang Guijun;Department of Otolaryngology Head and Neck Surgery,Chongqing General Hospital;;Observation of clinical effect of glucocorticoid and hyperbaric oxygen therapy on the high-frequency and diminishing sudden deafness[J];重庆医学;2017-14
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1 LIU Gen-jiu;LI Sui-qin;;The Clinical Effects of Batroxobin Combined with Vinpocetine in the Treatment of Senile Sudden Deafness[J];中国听力语言康复科学杂志;2016-05
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