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《Journal of Audiology and Speech Pathology》 2005-04
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Dexamethasone Pharmacokinetics in Perilymph and Plasma of Guinea Pig After Topical Administration and Intracardial Injection

Wu Hao,Yang Jun,Hou Dongming,et al. (Department of Otorhinolaryngology & Head-neck Surgery, Xinhua Hospital Affiliated Shanghai Second Medical University, Shanghai,200092,China)  
Objective To determine pharmacokinetics profiles of dexamethasone (DEX) in perilymph and plasma of guinea pig after topical and systemic administration.Methods A granule gelfoam soaked with DEX (10 mg/ml) was placed in the niche of round window of guinea pig; 0.5 mg/kg of DEX was injected intracardially. Samples of blood and perilymph of the scala tympani were obtained 1~6 h after administration of two routes respectively. High-performance liquid chromatography was used to assay DEX in the samples.Results After topical administration or intracardial injection of DEX, concentrations of drug in perilymph and plasma decreased gradually over time. DEX was not detectable in sample of plasma after topical administration. The concentration of DEX in perilymph after topical administration was significantly higher than that after intracardial injection (P=0.0035). The concentration of DEX in plasma after topical administration was significantly lower than that after intracardial injection (P=0.0096). After intracardial injection, the concentration of DEX in perilymph was significantly lower than that in plasma(P=0.0097). The half-life time of DEX in perilymph was 2.67 hours.Conclusion DEX could penetrate effectively through round window membrane into the cochlear fluid and reach a much higher concentration following topical administration as compared with systemic application.
【Fund】: 上海市科委资助课题(034119819)
【CateGory Index】: R96
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【References】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
2 SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China);Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation[J];Journal of Clinical Otorhinolaryngology;2006-16
3 PENG Yikun XIONG Shizheng CHENG Yonghua QI Yifei YANG Yang(Department of Otolaryngology, Guizhou Province People′s Hospital, Guiyang, 55002,China);Clinical investigation of different routes of administration of dexamethasone on sudden deafness[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-10
4 FANG Wenxu,CAI Zhifu,LIAO Zhiping Dept.of Otolaryngology,the Affiliated Hospital of Putian College,Fujian,351100,China;Comparative study on the therapeutic effect of intratympanic injecting therapy by diprospan with that of dexamethasone on sudden hearing loss[J];Chinese Otorhinolaryngological Journal of Integrative Medicine;2008-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SU Jiping 1 Bachmann G 2 TANG Anzhou 1 Zumegen C 2 Michel O 2 Wittekindt C 2 ( 1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021; 2Klinik und Poliklinik für Hals , Nasen , Ohrenheilkunde, der Universitt zu Kln);The different levels of prednisolone in perilymph after local and systemic treatment[J];Journal of Clinical Otorhinolaryngology;2003-10
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Shao Jun,Guo Guang-wei,Su Ji-ping(Department of Otolaryngology and Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Methylprednisolone of Intratympanic Injection for Refractory Sudden Sensorineural Hearing Loss[J];Guangxi Medical Journal;2009-06
2 CHEN Gang, HOU Shi-xiang~△, LIU Jun, LUAN Jian-gang, ZHANG Yu. Department of Pharmaceutical Sciences, West China School of Pharmacy,Sichuan University, Chengdu 610041, China;In vivo Distribution and Pharmacokinetics of Dexamethasone Sodium Phosphate Thermosensitive in situ Gel Following Intratympanic Injection[J];Journal of Sichuan University(Medical Science Edition);2006-03
3 LI Sui 1 GONG Shusheng 1 CHEN Jianguo 2 LU Haitao 1 WANG Jibao 1 ( 1Department of Otolaryngology,Union Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China; 2Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology);Pharmacokinetics of the methylprednisolone,dexamethasone and hydrocortisone in the inner ear after administered via round window[J];Journal of Clinical Otorhinolaryngology;2005-01
4 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 GUO Shu Yun 1, SUN Xiao Li 1, HUANG Wei Guo 2, LIU Shun Li 2 1Department of Chemistry, School of Basic Medicine, 2Department of Otorhinolaryngology, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China;Lysisin aspirin protects against gentamicin ototoxicity[J];Journal of The Fourth Military Medical University;2003-19
2 Wang Xiaoxia, Yao Xiaobao, Ji Xiansheng, et al. Department of Otolaryngology, 451 Hospital of PLA, Xian 710054;Hair cell protection of from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor[J];Guangdong Medical Journal;2003-08
3 XIONG Min, WANG Jian, HE Qing-lian, DENG Heng-shan Department of Otolaryngology of General Hospital of PLA Guangzhou Command, Guangzhou 510010, China;The anti-ototoxic effect of bFGF perfusion to cochlea with micro-osmotic pump in guinea pig[J];West China Journal of Pharmaceutical Sciences;2003-05
4 SU Jiping 1 Bachmann G 2 TANG Anzhou 1 Zumegen C 2 Michel O 2 Wittekindt C 2 ( 1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021; 2Klinik und Poliklinik für Hals , Nasen , Ohrenheilkunde, der Universitt zu Kln);The different levels of prednisolone in perilymph after local and systemic treatment[J];Journal of Clinical Otorhinolaryngology;2003-10
5 LU Yongde REN Jihao WU Weijing YIN Tuanfang YANG Xinming XIE Dinghua (Department of Otorhinolaryngology, the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China);Intratympanic dexamethasone injections for intractable Meniere's disease[J];Journal of Clinical Otorhinolaryngology;2004-07
6 LI Sui 1 GONG Shusheng 1 CHEN Jianguo 2 LU Haitao 1 WANG Jibao 1 ( 1Department of Otolaryngology,Union Hospital, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China; 2Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology);Pharmacokinetics of the methylprednisolone,dexamethasone and hydrocortisone in the inner ear after administered via round window[J];Journal of Clinical Otorhinolaryngology;2005-01
7 HOU Dongming 1 WU Hao 1 YANG Jun 1 ZHANG Ping 1 ZHANG Shunguo 2 CHEN Jie 1 ( 1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China; 2Department of Clinical Pharmacology, Xinhua Hospital, Shanghai Second Medical University);Dexamethasone pharmacokinetics in perilymph of guinea pig after different topical administrations[J];Journal of Clinical Otorhinolaryngology;2005-07
8 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
9 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
10 REN Jihao LU Yongde YIN Tuanfang LIU Bin GE Yilin (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone injections for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-05
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 Deng Cuiping,Lin Haiyan,Ou Yongkan;Nursing for patients with sudden deafness treated by Jiaqiangnong drum injection under ear endoscope[J];Journal of Nurses Training;2008-15
2 SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China);Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation[J];Journal of Clinical Otorhinolaryngology;2006-16
3 JIA Daijie QIN Zhaobing LU Wei LI Sujuan CHEN Xiaohua(Department of Otorhinolaryngology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China);Intratympanic dexamethasone for refractory sudden deafness[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-07
4 PENG Yikun XIONG Shizheng CHENG Yonghua QI Yifei YANG Yang(Department of Otolaryngology, Guizhou Province People′s Hospital, Guiyang, 55002,China);Clinical investigation of different routes of administration of dexamethasone on sudden deafness[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2008-10
5 TONG Jun,CAI Xun-hua,CHEN Wen-wen (Department of Otolaryngology & Head and Neck Surgery,Branch of Shanghai First People′s Hospital,Shanghai 200081,China);Terapeutic effects of sudden sensorineural hearing loss in old and young[J];Journal of Otolaryngology and Ophthalmology of Shandong University;2007-06
6 YANG Jun,WU Hao,HOU Dong-ming,CHEN Jie,ZHANG Ping (Department of Otolaryngology-Head & Neck Surgery,Xinhua Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China);Pharmacokinetic profiles of corticosteroid in perilymph and plasma after systemic and transtympanic administration[J];Journal of Shanghai Jiaotong University(Medical Science);2007-01
7 ZHANG Jing-hua,WU Hao (Department of Otolaryngology-Head & Neck Surgery,Xinhua Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China);Model of immune-mediated inner ear disease and efficacy of dexamethasone by systemic application or round window administration[J];Journal of Shanghai Jiaotong University(Medical Science);2007-01
8 Cao Wei,Qiu Jianxin,Zhang Kunling,et al(Dept of Otolaryngology-Head & Neck Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022);Intratympanic methylprednisolone medication for intractable sudden sensorineural hearing loss[J];Acta Universitatis Medicinalis Anhui;2007-05
9 ;突聋患者心理障碍及护理干预[J];China Practical Medicine;2010-03
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