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《Journal of Audiology and Speech Pathology》 2007-06
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Transtympanic Prednisolone Treatment for Subjective Tinnitus

She Wandong,Dai Yanhong,Chen Feng,et al.(Department of Otorhinolaryngology,The Affiliated Drum Tower Hospital,Nanjing University Medical School,Nanjing 210008,China)  
Objective To determine whether transtympanic steroid administration may be an effective treatment for subjective tinnitus(ST) in patients for whom routine systemic drug treatment has failed over four weeks after onset.Methods A prospective study was designed to evaluate the tinnitus outcomes in ST patients treated with transtympanic prednisolone.29 cases(30 ears) in the study group received transtympanic prednisolone and oral vitamin B and vasodilator agent.25 ears in the control group only received above drugs orally for one month.Transtympanic prednisolone was administered through tympanic puncture under local anesthesia.Prednisolone administration was performed twice in the first week and once a week in the next three weeks.Loudness of tinnitus was assessed immediately before the injection and within one week after the injection.Results In the study group there were 14 cases with idiopathic sudden hearing loss,4 cases with presbycusis,3 cases with noise-induced hearing loss,1 case with otosclerosis,2 cases with idiopathic tinnitus,the others whose etiology were unclear were 5 cases with sensorineural hearing loss,2 cases with mixed hearing loss and 1 case with conductive hearing loss.Tinnitus improvement was obtained in 16 of 30 ears who underwent the completion of therapy.The intensity of tinnitus was only lowered in the 6 ears in the control group.Conclusion Transtympanic prednisolone therapy may be an alternative choice for patients with ST in whom routine systemic therapy had failed.
【Fund】: 南京市医学科技发展项目(编号YKK05098)
【CateGory Index】: R764.45
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Chinese Journal Full-text Database 2 Hits
1 SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China);Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation[J];Journal of Clinical Otorhinolaryngology;2006-16
2 Liu Xiang,Zheng Yiqing,Zhang Zhigang,et al.(Department of Otolaryngology,2nd Affiliated Hospital of Sun Yat-sen University,Guangzhou,510120,China);A Review of the Short-term Outcomes of Transtympanic Methylprednisolone Injection for Intractable Idiopathic Sudden Sensorineural Hearing Loss[J];Journal of Audiology and Speech Pathology;2008-04
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