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《Journal of Audiology and Speech Pathology》 2008-04
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A Review of the Short-term Outcomes of Transtympanic Methylprednisolone Injection for Intractable Idiopathic Sudden Sensorineural Hearing Loss

Liu Xiang,Zheng Yiqing,Zhang Zhigang,et al.(Department of Otolaryngology,2nd Affiliated Hospital of Sun Yat-sen University,Guangzhou,510120,China)  
Objective To evaluate the short-term outcomes and related complications of transtympanic methylprednisolone injection for intractable idiopathic sudden sensorineural hearing loss(SSNHL).Methods Studied were 30 patients who had received transtympanic methylprednisolone injection after having failed with intravenous steroids and other medications from Jan 2006 to Feb 2007.They all had received intravenous dexamethasone and other medications for two weeks and no improvement of hearing.The transtympanic methylprednisolone injections were administered with oto-endoscope once a week for 3 weeks.Hearing and tympanic membrane were monitered one month after the termination of injections.Hearing improvement was defined as more than 10 dB in pure-tone average(PTA).Results 9 patients had improvement of hearing(30%) according to the PTA.The thresholds of 500,1 000 and 2 000 Hz decreased obviously(P0.01).No membrane perforation and vertigo were reported.Conclusion Transtympanic methylprednisolone injection can be considered as a salvage treatment for intractable SSNHL.
【CateGory Index】: R764
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
2 Wang Liyi, Huang Weining (Department of Otolaryngology, Beijing Hospital, Beijing, 100730, China);Effectiveness of Intratympanic Dexamethasone Injection in Sudden Deafness Patients as Salvage Treatment[J];Journal of Audiology and Speech Pathology;2007-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LUO Zhongmei;Intratympanic Dexamethasone Injection for Sudden Sensorineural Hearing Loss and Nursing Care[J];Journal of Nursing Science;2009-04
2 MAO Yanjiao WANG Wei (Department of Otorhinolaryngology, No.4 Hospital of Hangzhou, Hangzhou,310002,China);Clinical study of acute low-tone sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-13
3 SUN Xialing REN Jihao LU Yongde YIN TuanfangWU Weijing TANG Yueying HU Binya(Department of Otolaryngology,the Second Hospital of Xiangya Medical College,Central South University,Changsha, 410011,China );Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2007-04
4 LI Zhen-cai,FENG Jie,ZHANG Xin-fang,PENG Xiu-hua,YOU Mei(Department of Otorhinolaryngology,Binzhou People′s Hospital,Binzhou 256617,Shandong,China);Dexamethasone injection in the middle ear for sudden deafness[J];Journal of Otolaryngology and Ophthalmology of Shandong University;2006-06
5 Wang Liyi, Huang Weining (Department of Otolaryngology, Beijing Hospital, Beijing, 100730, China);Effectiveness of Intratympanic Dexamethasone Injection in Sudden Deafness Patients as Salvage Treatment[J];Journal of Audiology and Speech Pathology;2007-04
6 Dai Yanhong,She Wandong,Du Xiaoping,et al.(Department of Otolaryngology-Head and Neck Surgery,the Affiliated Drum Tower Hospital,Nanjing University Medical School,Nanjing,210008,China);The Evaluation of Intratympanic Methylprednisolone Perfusion as a Salvage Treatment for Sudden Sensorineural Hearing Loss[J];Journal of Audiology and Speech Pathology;2008-06
7 Zhai Suoqiang,Yu Ning,Zheng Guiliang,Zhu Yuhua,Qin He(Hospital of Otorhinolaryngology Head & Neck Surgery,Chinese PLA General Hospital,Beijing,100853,China);The Clinical Observation the Effects of the Re-Therapeutic on the Later Stage of Sudden Deafness[J];Journal of Audiology and Speech Pathology;2010-01
8 CHANG Wen-xu,ZHONG Hui-ling,CAI Xiao,et al.The People′s Hospital of Qinghai,Xining,Qinghai 810007,China;Dexamethasone injection in the middleear for high altitude refractory suddendeafness[J];Sichuan Medical Journal;2010-01
9 Fei Jie,Zhou Weidong,Li Jihong(Medical College of Nanjing University,Nanjing,210093,China);Intratympanic Dexamethasone in the Treatment of Acute Low-Frequency Hearing Loss[J];Journal of Audiology and Speech Pathology;2010-02
10 Cao Wei,Qiu Jianxin,Zhang Kunling,et al(Dept of Otolaryngology-Head & Neck Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022);Intratympanic methylprednisolone medication for intractable sudden sensorineural hearing loss[J];Acta Universitatis Medicinalis Anhui;2007-05
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China);Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation[J];Journal of Clinical Otorhinolaryngology;2006-16
2 She Wandong,Dai Yanhong,Chen Feng,et al.(Department of Otorhinolaryngology,The Affiliated Drum Tower Hospital,Nanjing University Medical School,Nanjing 210008,China);Transtympanic Prednisolone Treatment for Subjective Tinnitus[J];Journal of Audiology and Speech Pathology;2007-06
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 YANG Jun1 HUANG Li1 SHI Jun1 LI Yun1 WU Hao1 KONG Weijia2(1Department of Otorhinolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Jiaotong University School of Medicine Ear Institute,Shanghai,200092,China;2Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology);The effect of intratympanic dexamethasone or methylprednisolone on treatment of sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology Head and Neck Surgery;2010-13
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LU Yongde REN Jihao WU Weijing YIN Tuanfang TANG Yueying XIE Dinghua (Department of Otolaryngology, the Second Hospital of Xiangya Medical College, Central South University, Changsha, 410011, China);Intratympanic dexamethasone for sudden sensorineural hearing loss[J];Journal of Clinical Otorhinolaryngology;2006-01
2 She Wandong, Dai Yanhong, Chen Feng,et al. (Department of Otorhinolaryngology, The Affiliated Drum Tower Hospital, Nanjing University Medical School,Nanjing,210008, China);Transtympanic Prednisolone Treatment for Idiopathic Sudden Sensorineural Hearing Loss[J];Journal of Audiology and Speech Pathology;2005-05
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