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《Natural Product Research and Development》 1994-03
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ANTI-ANOXIC ACTIONS OF DAPHNETIN IN INTACT MICE

Zhang Mingfa,Shen Yaqin (Department of pharmacology,Shaanxi Acadeny of Traditional Chinese Medicine,Xian 710003)  
Daphnetin,300 and 600 mg/kg ig,prolonged decapitaion-induced gasping duration in mice,and prolonged the survival time in mice poisoned by iv KCN or ip NaNO2.The actions were enhanced in a dose-dependent manner.Daphnetin did not prolong the survival time of mice under the condition of the normobaric hypoxia,but it antagonized the effects of increasing the velocity of O2 consumption and decreasing the survival time by ip isoprenaline.
【CateGory Index】: R96
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