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《Natural Product Research and Development》 2005-06
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Effect of Fruit of Nitraria tangutorum Bobr. from Qaidam Basin on Immunomodulatory,Anti-fatigue and Cold-tolerance

SUO You-rui 1*,LI Yu-lin 1,2,WANG Hong-lun 1,2,YU Jing 2,3,CHEN Gui-chen1 (1.Northwest Plateau Institute of Biology,Chinese Academy of Sciences,Xining 810001,China; 2.Graduate School of the Chinese Academy of Sciences,Beijing 100039,China; 3.Affiliated Second Hospital,Lanzhou Medical College,Lanzhou 730030,China)  
In the study,the immunomodulatory effects of fruit of Nitraria tangutorum Bobr.(FNTB)from Qinghai Tsaidam Basin were studied on cyclophosphamide(CPA)model mice.Furthmore,the functions of anti-fatigue and cold-tolerance of FNTB were put to the test.The experimental results showed that FNTB ig 3.6 g/kg remarkably strengthened phagocytosing function of the monocyte-macrophage system,delayed type hypersensitivity reaction in mice treated by CPA.FNTB ig 1.8 g/kg or 3.6 g/kg,and significantly increased the development of serum hemolysin in model mice.FNTB ig 3.6 g/kg notably enhanced the DNA content of thymus in CPA-treated mice.Moreover,FNTB ig 3.6 g/kg significantly prolonged the swimming time and climbing time of the mice,and the existing time of the FNTB groups were obviously higher than that of the controlled group.The result indicated that FNTB has significant immunomodulatory,anti-fatigue and cold-tolerance effect on the mice.
【Fund】: 国家科技攻关计划项目(2001BA901A47);; 中国科学院“西部之光”人才培养计划项目
【CateGory Index】: R285
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