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《Natural Product Research and Development》 2006-03
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Studies on Immunomodulation of Polysaccharidefrom Dendrobium thyrsiflorum Rchb.f

SONG Ning1,LU Ying 1*,QIU Ming-hua2(1Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Kunming 650031,China; 2Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China)  
The objective of this study was to evaluate the effects of Dendrobium thyrsiflorum Rchb.f polysaccharide (DTP)on immune function in normal mice.The DTP was obtained by alkali extraction and alcohol precipitation from Dendrobium thyrsiflorum Rchb.f and was administered on normal mice with 400 mg/kg,600 mg/kg and 800 mg/kg respectively through stomach for 10 d .The weight of immune organs,engulfing carbon granula test,T、B lymphocyte transformation test of mouse spleen cell were investigated to determin the effects of DTP on immune function.The results show that the spleen index in low and middle dosage treatment was higher than that of control group(P0.01).The macrophage engulfing carbon granula ability and B lymphocyte proliferation ability in middle and high dosage treatment are higher than that of control group(P0.01,P0.05).These findings indicate that DTP could significantly increase spleen weight,macrophage engulfing carbon granula ability and B lymphocyte proliferation capacity.So the conclusion is that DTP could enhance the immune function in mice and would be a good immunomodulater.
【Fund】: 云南省教育厅科研基金项目(5J0344C)
【CateGory Index】: R285.5
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