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Labeling of Annexin V With ~(125)I and Its Biodistribution in Mice

JIN Cai-ling~1,XU Yu-jie~1,FAN Wo~1,HUA Zi-chun~2,HU Ming-jiang~1,WANG Dao-jin~1,ZHU Ran~1,ZHANG You-jiu~1(1.School of Radiation Medicine and Public Health,Suzhou University,Suzhou 215007,China; 2.State Key Laboratory of Medical Biology Technology,Nanjing University,Nanjing 210093,China)  
Annexin V is labeled with ~(125)I by using Iodogen method and the biodistribution of which in mice is investigated.The labeling yield of ~(125)I-Annexin V is 94.9% and its radiochemical purity is over 99% after parification.The radioactivity uptake is the highest in kidney,followed in order by blood,liver,heart,lung and spleen;no uptake in brain;the lower in muscle and bone;The uptake of the selected tissues is decreased rapidly at 1 hour after injection except blood.The results show that it is a excellent imaging agent for diagnoses.
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